Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 1782529..1783222 | Replicon | chromosome |
| Accession | NZ_AP018538 | ||
| Organism | Enterococcus faecalis strain KUB3006 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | A0A2Z6BTE2 |
| Locus tag | EL240_RS09110 | Protein ID | WP_002364356.1 |
| Coordinates | 1782878..1783222 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | EL240_RS09105 | Protein ID | WP_002364355.1 |
| Coordinates | 1782529..1782861 (+) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EL240_RS09060 | 1778246..1779001 | - | 756 | WP_002391449.1 | DnaD domain protein | - |
| EL240_RS09065 | 1779016..1779831 | - | 816 | WP_010783770.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
| EL240_RS09070 | 1779794..1780810 | - | 1017 | WP_010783771.1 | recombinase RecT | - |
| EL240_RS09080 | 1780913..1781137 | - | 225 | WP_002391454.1 | hypothetical protein | - |
| EL240_RS09085 | 1781134..1781457 | - | 324 | WP_010783772.1 | hypothetical protein | - |
| EL240_RS09090 | 1781497..1781712 | - | 216 | WP_010783773.1 | hypothetical protein | - |
| EL240_RS09095 | 1781719..1782030 | - | 312 | WP_002381719.1 | hypothetical protein | - |
| EL240_RS09100 | 1782041..1782217 | - | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
| EL240_RS09105 | 1782529..1782861 | + | 333 | WP_002364355.1 | helix-turn-helix domain-containing protein | Antitoxin |
| EL240_RS09110 | 1782878..1783222 | + | 345 | WP_002364356.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| EL240_RS09115 | 1783316..1784221 | + | 906 | WP_016630909.1 | DUF4352 domain-containing protein | - |
| EL240_RS09125 | 1784389..1785117 | + | 729 | WP_002364358.1 | ion transporter | - |
| EL240_RS09130 | 1785213..1786361 | + | 1149 | WP_010783774.1 | site-specific integrase | - |
| EL240_RS09135 | 1786389..1786832 | - | 444 | WP_033786344.1 | cleavage protein | - |
| EL240_RS09140 | 1786829..1787104 | - | 276 | WP_002356991.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| EL240_RS09145 | 1787104..1788150 | - | 1047 | WP_033786346.1 | type II secretion system F family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1746817..1805211 | 58394 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13704.62 Da Isoelectric Point: 5.8535
>T31848 WP_002364356.1 NZ_AP018538:1782878-1783222 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
Download Length: 345 bp
>T31848 NZ_AP018538:1782878-1783222 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATCCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCGGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAAGAAACTTATTTAAATTAA
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATCCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCGGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAAGAAACTTATTTAAATTAA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12691.16 Da Isoelectric Point: 4.6307
>AT31848 WP_002364355.1 NZ_AP018538:1782529-1782861 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT31848 NZ_AP018538:1782529-1782861 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|