Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2672076..2672669 Replicon chromosome
Accession NZ_AP018515
Organism Acetobacter orientalis strain FAN1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AcetOrient_RS12110 Protein ID WP_126621434.1
Coordinates 2672487..2672669 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AcetOrient_RS12105 Protein ID WP_126621433.1
Coordinates 2672076..2672468 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AcetOrient_RS12070 2667545..2668171 + 627 WP_126621427.1 hypothetical protein -
AcetOrient_RS14910 2668171..2669844 + 1674 WP_197719550.1 hypothetical protein -
AcetOrient_RS12080 2669871..2670176 + 306 WP_126621428.1 hypothetical protein -
AcetOrient_RS12085 2670270..2670572 + 303 WP_126621429.1 hypothetical protein -
AcetOrient_RS12090 2670569..2671051 + 483 WP_126621430.1 hypothetical protein -
AcetOrient_RS12095 2671320..2671625 + 306 WP_126621431.1 hypothetical protein -
AcetOrient_RS12100 2671622..2671855 + 234 WP_126621432.1 hypothetical protein -
AcetOrient_RS12105 2672076..2672468 - 393 WP_126621433.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AcetOrient_RS12110 2672487..2672669 - 183 WP_126621434.1 type II toxin-antitoxin system HicA family toxin Toxin
AcetOrient_RS12120 2674306..2675277 + 972 WP_048842103.1 complex I NDUFA9 subunit family protein -
AcetOrient_RS12125 2675455..2676906 + 1452 WP_048842104.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2622785..2675277 52492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6717.87 Da        Isoelectric Point: 10.9132

>T31837 WP_126621434.1 NZ_AP018515:c2672669-2672487 [Acetobacter orientalis]
MNSAALIKEMKKAGWYEVRVRGSHHQFKHPDFGHTVTVPHPQKELGKGLVAAIKKQTGLK

Download         Length: 183 bp

>T31837 NZ_AP018515:c2672669-2672487 [Acetobacter orientalis]
ATGAACAGCGCAGCACTCATCAAAGAAATGAAAAAGGCCGGTTGGTATGAAGTCCGGGTTCGCGGATCACACCACCAGTT
CAAGCACCCTGACTTTGGTCACACAGTCACGGTGCCGCACCCCCAAAAAGAACTGGGCAAAGGTCTTGTAGCTGCCATCA
AAAAACAAACCGGGCTGAAATAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14154.09 Da        Isoelectric Point: 4.4719

>AT31837 WP_126621433.1 NZ_AP018515:c2672468-2672076 [Acetobacter orientalis]
MRYPIVIEMPTSEKEAYGVVFPDLPGCFSAGDTLDEAITNASEAAALWIESTLDDGGKVPPPSSFEVVRNNPKWAGWVLA
VANVDPMLFDSSAERVNITLPKRVLARLDRRAKEEGDTRSGFIARLAMSA

Download         Length: 393 bp

>AT31837 NZ_AP018515:c2672468-2672076 [Acetobacter orientalis]
ATGCGCTACCCAATCGTGATTGAGATGCCTACAAGTGAGAAAGAAGCTTACGGCGTTGTGTTTCCTGACCTGCCCGGCTG
CTTCTCTGCTGGCGATACATTAGATGAAGCCATCACTAATGCCTCTGAGGCCGCTGCACTGTGGATTGAGAGTACGTTAG
ATGATGGTGGAAAGGTGCCACCCCCTTCGTCTTTTGAGGTCGTAAGGAATAATCCAAAATGGGCCGGATGGGTGCTGGCT
GTAGCCAACGTTGACCCGATGCTGTTCGATAGCTCGGCGGAGCGCGTGAATATAACGCTCCCTAAGCGTGTCTTGGCGCG
CCTTGATCGTCGGGCAAAAGAAGAAGGCGACACGCGTTCAGGGTTTATTGCTCGCTTGGCTATGAGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References