31809

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2125605..2126076 Replicon chromosome
Accession NZ_AP018488
Organism Escherichia coli O157:H7 strain PV15-279

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag ECpv15279_RS10870 Protein ID WP_001303511.1
Coordinates 2125798..2126076 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag ECpv15279_RS10865 Protein ID WP_001302048.1
Coordinates 2125605..2125796 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECpv15279_RS10825 2120811..2121395 - 585 WP_000206793.1 DUF551 domain-containing protein -
ECpv15279_RS10830 2121452..2121847 - 396 WP_001118159.1 DUF977 family protein -
ECpv15279_RS10835 2121863..2122633 - 771 WP_000450876.1 DUF1627 domain-containing protein -
ECpv15279_RS10840 2122659..2123399 - 741 WP_000788938.1 ATP-binding protein -
ECpv15279_RS10845 2123406..2124368 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
ECpv15279_RS10850 2124391..2124816 - 426 WP_000693943.1 Rha family transcriptional regulator -
ECpv15279_RS10855 2124813..2125115 - 303 WP_000172738.1 transcriptional regulator -
ECpv15279_RS10860 2125213..2125584 + 372 WP_001169686.1 hypothetical protein -
ECpv15279_RS10865 2125605..2125796 + 192 WP_001302048.1 hypothetical protein Antitoxin
ECpv15279_RS10870 2125798..2126076 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECpv15279_RS10875 2126429..2126728 + 300 WP_001240334.1 hypothetical protein -
ECpv15279_RS10880 2126801..2127019 + 219 WP_001171904.1 hypothetical protein -
ECpv15279_RS10890 2127588..2127776 + 189 WP_000449192.1 cell division inhibition protein DicB -
ECpv15279_RS10895 2127773..2127964 + 192 WP_001090200.1 DUF1482 family protein -
ECpv15279_RS10900 2128057..2129388 + 1332 WP_197724719.1 exonuclease -
ECpv15279_RS10915 2130781..2131032 + 252 WP_000005552.1 excisionase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' / paa / nleC / nleC / stx2B / stx2A / espM1 / nleH2 / nleA/espI 1989300..2174509 185209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T31809 WP_001303511.1 NZ_AP018488:2125798-2126076 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T31809 NZ_AP018488:2125798-2126076 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT31809 WP_001302048.1 NZ_AP018488:2125605-2125796 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT31809 NZ_AP018488:2125605-2125796 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
AlphaFold DB A0A829CTP0

References