Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2125605..2126076 | Replicon | chromosome |
| Accession | NZ_AP018488 | ||
| Organism | Escherichia coli O157:H7 strain PV15-279 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ECpv15279_RS10870 | Protein ID | WP_001303511.1 |
| Coordinates | 2125798..2126076 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ECpv15279_RS10865 | Protein ID | WP_001302048.1 |
| Coordinates | 2125605..2125796 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECpv15279_RS10825 | 2120811..2121395 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| ECpv15279_RS10830 | 2121452..2121847 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| ECpv15279_RS10835 | 2121863..2122633 | - | 771 | WP_000450876.1 | DUF1627 domain-containing protein | - |
| ECpv15279_RS10840 | 2122659..2123399 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| ECpv15279_RS10845 | 2123406..2124368 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ECpv15279_RS10850 | 2124391..2124816 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ECpv15279_RS10855 | 2124813..2125115 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| ECpv15279_RS10860 | 2125213..2125584 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| ECpv15279_RS10865 | 2125605..2125796 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ECpv15279_RS10870 | 2125798..2126076 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ECpv15279_RS10875 | 2126429..2126728 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| ECpv15279_RS10880 | 2126801..2127019 | + | 219 | WP_001171904.1 | hypothetical protein | - |
| ECpv15279_RS10890 | 2127588..2127776 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ECpv15279_RS10895 | 2127773..2127964 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ECpv15279_RS10900 | 2128057..2129388 | + | 1332 | WP_197724719.1 | exonuclease | - |
| ECpv15279_RS10915 | 2130781..2131032 | + | 252 | WP_000005552.1 | excisionase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' / paa / nleC / nleC / stx2B / stx2A / espM1 / nleH2 / nleA/espI | 1989300..2174509 | 185209 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T31809 WP_001303511.1 NZ_AP018488:2125798-2126076 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T31809 NZ_AP018488:2125798-2126076 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT31809 WP_001302048.1 NZ_AP018488:2125605-2125796 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT31809 NZ_AP018488:2125605-2125796 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|