Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1153967..1154445 Replicon chromosome
Accession NZ_AP018488
Organism Escherichia coli O157:H7 strain PV15-279

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ECpv15279_RS05435 Protein ID WP_001303876.1
Coordinates 1153967..1154254 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ECpv15279_RS05440 Protein ID WP_000536233.1
Coordinates 1154254..1154445 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECpv15279_RS05400 1149117..1151588 - 2472 WP_000034474.1 exonuclease -
ECpv15279_RS05405 1151682..1151873 - 192 WP_001098307.1 DUF1482 family protein -
ECpv15279_RS05410 1151870..1152058 - 189 WP_000413706.1 hypothetical protein -
ECpv15279_RS05420 1152632..1152817 + 186 WP_001133046.1 hypothetical protein -
ECpv15279_RS05425 1153004..1153393 - 390 WP_000394511.1 hypothetical protein -
ECpv15279_RS05430 1153535..1153690 - 156 WP_000379575.1 DUF1391 family protein -
ECpv15279_RS05435 1153967..1154254 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECpv15279_RS05440 1154254..1154445 - 192 WP_000536233.1 hypothetical protein Antitoxin
ECpv15279_RS05445 1154473..1154874 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ECpv15279_RS05450 1154983..1155255 + 273 WP_000887446.1 helix-turn-helix domain-containing protein -
ECpv15279_RS05455 1155239..1155664 + 426 WP_000693855.1 Rha family transcriptional regulator -
ECpv15279_RS05460 1155871..1156326 - 456 WP_000273724.1 hypothetical protein -
ECpv15279_RS05465 1156405..1157496 + 1092 WP_001205823.1 hypothetical protein -
ECpv15279_RS05470 1157503..1158249 + 747 WP_000788751.1 ATP-binding protein -
ECpv15279_RS05475 1158271..1159041 + 771 WP_000450992.1 DUF1627 domain-containing protein -
ECpv15279_RS05480 1159057..1159293 + 237 Protein_1047 DUF977 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T31799 WP_001303876.1 NZ_AP018488:c1154254-1153967 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T31799 NZ_AP018488:c1154254-1153967 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT31799 WP_000536233.1 NZ_AP018488:c1154445-1154254 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT31799 NZ_AP018488:c1154445-1154254 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References