Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 2564548..2565055 Replicon chromosome
Accession NZ_AP018449
Organism Methylomusa anaerophila strain MMFC1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MAMMFC1_RS11560 Protein ID WP_126308656.1
Coordinates 2564548..2564805 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MAMMFC1_RS11565 Protein ID WP_126308657.1
Coordinates 2564798..2565055 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAMMFC1_RS11545 2562434..2562781 - 348 WP_158618740.1 hypothetical protein -
MAMMFC1_RS11550 2562954..2563130 + 177 WP_126308654.1 hypothetical protein -
MAMMFC1_RS11555 2563123..2564439 + 1317 WP_126308655.1 UDP-glucose/GDP-mannose dehydrogenase family protein -
MAMMFC1_RS11560 2564548..2564805 - 258 WP_126308656.1 Txe/YoeB family addiction module toxin Toxin
MAMMFC1_RS11565 2564798..2565055 - 258 WP_126308657.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MAMMFC1_RS11570 2565273..2566655 + 1383 WP_126310584.1 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase -
MAMMFC1_RS11575 2566670..2568049 + 1380 WP_126308658.1 phosphomannomutase -
MAMMFC1_RS11580 2568173..2568451 + 279 WP_126308659.1 type II toxin-antitoxin system ParD family antitoxin -
MAMMFC1_RS11585 2568661..2568978 + 318 WP_158618741.1 nucleotidyltransferase domain-containing protein -
MAMMFC1_RS11590 2568954..2569352 + 399 WP_126308661.1 HI0074 family nucleotidyltransferase substrate-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10394.86 Da        Isoelectric Point: 6.4817

>T31793 WP_126308656.1 NZ_AP018449:c2564805-2564548 [Methylomusa anaerophila]
MNKVFTDIAWEDYLYWQTTDKKVLKKIHELIKDIERHGNEGLGKPEPLKYELEGLWSRRITPEHRLIYKFDDENIYILQC
RGHYD

Download         Length: 258 bp

>T31793 NZ_AP018449:c2564805-2564548 [Methylomusa anaerophila]
ATGAATAAAGTTTTTACCGATATTGCCTGGGAAGACTATCTATATTGGCAAACCACGGATAAAAAAGTATTAAAGAAGAT
CCATGAGTTAATTAAGGATATTGAACGGCACGGAAATGAAGGGCTAGGCAAACCTGAACCTCTTAAATACGAATTAGAAG
GCTTATGGAGCAGGAGAATCACTCCGGAACATAGGCTTATTTACAAATTTGACGATGAAAATATTTATATCCTGCAATGT
CGTGGTCACTATGATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9899.22 Da        Isoelectric Point: 6.3247

>AT31793 WP_126308657.1 NZ_AP018449:c2565055-2564798 [Methylomusa anaerophila]
MLAVNYSSVRENFKTYCDKANNDFETIVITRKQGGNVVLLSEAEYNNIMENLFIRSNKKTYDRLLESMEQLKSGKAQTRK
IIEDE

Download         Length: 258 bp

>AT31793 NZ_AP018449:c2565055-2564798 [Methylomusa anaerophila]
ATGTTGGCTGTAAACTATTCAAGTGTAAGGGAAAATTTTAAAACCTATTGCGATAAAGCGAATAATGATTTTGAAACAAT
TGTTATTACCCGCAAGCAAGGCGGTAACGTTGTTTTGCTTTCAGAAGCTGAATACAACAATATTATGGAAAATCTGTTTA
TCCGCAGCAATAAGAAAACTTACGACAGGCTTTTAGAATCAATGGAACAATTGAAGTCAGGCAAAGCCCAAACCAGAAAA
ATTATCGAAGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References