Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 2486906..2487473 Replicon chromosome
Accession NZ_AP018449
Organism Methylomusa anaerophila strain MMFC1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MAMMFC1_RS11250 Protein ID WP_126308598.1
Coordinates 2486906..2487157 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MAMMFC1_RS11255 Protein ID WP_126308599.1
Coordinates 2487147..2487473 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAMMFC1_RS11225 2482014..2483063 + 1050 WP_126308594.1 putative lipopolysaccharide heptosyltransferase III -
MAMMFC1_RS11230 2483044..2484216 + 1173 WP_126308595.1 glycosyltransferase -
MAMMFC1_RS11235 2484443..2485537 + 1095 WP_126310579.1 lipopolysaccharide heptosyltransferase II -
MAMMFC1_RS11240 2485577..2485996 + 420 WP_126308596.1 hypothetical protein -
MAMMFC1_RS11245 2486061..2486828 + 768 WP_126308597.1 glycosyltransferase family 2 protein -
MAMMFC1_RS11250 2486906..2487157 + 252 WP_126308598.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
MAMMFC1_RS11255 2487147..2487473 + 327 WP_126308599.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
MAMMFC1_RS11260 2487552..2488118 + 567 WP_126308600.1 D-sedoheptulose 7-phosphate isomerase -
MAMMFC1_RS11265 2488192..2489112 + 921 WP_126310580.1 D-glycero-beta-D-manno-heptose-7-phosphate kinase -
MAMMFC1_RS11270 2489257..2490219 + 963 WP_126308601.1 ADP-glyceromanno-heptose 6-epimerase -
MAMMFC1_RS11275 2490328..2490723 + 396 WP_126308602.1 GxxExxY protein -
MAMMFC1_RS11280 2490843..2491139 + 297 WP_126308603.1 hypothetical protein -
MAMMFC1_RS11285 2491278..2491811 + 534 WP_126308604.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(6-48)

Antitoxin

mRNA interferase PemK-like

(7-106)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9341.77 Da        Isoelectric Point: 4.7729

>T31791 WP_126308598.1 NZ_AP018449:2486906-2487157 [Methylomusa anaerophila]
MQADIVKIGNSRGIRLPATILKQCGIGSKVELEIKDNKIILKPVKTPRQGWAAAFKRMNQNDDDILLIPDDVDADLLEEW
NEN

Download         Length: 252 bp

>T31791 NZ_AP018449:2486906-2487157 [Methylomusa anaerophila]
ATGCAAGCGGATATTGTGAAAATCGGTAATTCCAGGGGAATAAGGCTTCCGGCCACGATACTTAAACAATGTGGCATAGG
TTCTAAAGTGGAACTGGAAATCAAAGATAACAAGATTATTTTAAAGCCGGTTAAAACGCCACGGCAAGGGTGGGCCGCAG
CATTTAAACGAATGAATCAAAATGATGACGATATTTTACTAATCCCTGATGATGTTGATGCCGACCTATTAGAGGAATGG
AATGAAAATTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12319.41 Da        Isoelectric Point: 9.0579

>AT31791 WP_126308599.1 NZ_AP018449:2487147-2487473 [Methylomusa anaerophila]
MKIDQYSVYWVDLNPTRGAEMNKTRPCVVISPLEMNTYLRTIIIAPVTRRGREGYPTRIKLAVNDVSGWIVLDQIRAIDK
TRLCEKIGNLTNGEIAEAKNIIKEMLVD

Download         Length: 327 bp

>AT31791 NZ_AP018449:2487147-2487473 [Methylomusa anaerophila]
ATGAAAATTGACCAATATTCCGTGTACTGGGTGGATTTAAACCCCACCCGAGGCGCGGAGATGAATAAGACAAGACCCTG
TGTAGTTATCTCTCCACTGGAGATGAACACTTATTTGCGAACCATCATAATTGCACCGGTAACGAGGCGGGGCAGGGAGG
GATACCCTACTCGTATAAAATTGGCTGTGAATGATGTATCAGGCTGGATTGTATTAGACCAAATCCGGGCTATAGATAAA
ACTAGACTCTGTGAAAAAATAGGGAATCTAACCAACGGCGAAATAGCAGAGGCAAAAAATATTATCAAGGAAATGCTGGT
TGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References