Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazE-Fic/MazF(toxin)
Location 1508364..1509420 Replicon chromosome
Accession NZ_AP018447
Organism Helicobacter cinaedi strain P06D0798

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DOM81_RS07635 Protein ID WP_014667079.1
Coordinates 1509109..1509420 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name Fic Uniprot ID -
Locus tag DOM81_RS07630 Protein ID WP_002955285.1
Coordinates 1508364..1509086 (-) Length 241 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOM81_RS07595 1503652..1503912 - 261 WP_110558609.1 hypothetical protein -
DOM81_RS07600 1503896..1504466 - 571 Protein_1500 metallophosphoesterase -
DOM81_RS07605 1504497..1504877 - 381 WP_110581555.1 Fic family protein -
DOM81_RS07610 1504883..1505248 - 366 WP_014667074.1 hypothetical protein -
DOM81_RS07620 1505364..1506523 - 1160 Protein_1503 transcriptional regulator -
DOM81_RS07625 1506504..1508348 - 1845 WP_110581553.1 hypothetical protein -
DOM81_RS07630 1508364..1509086 - 723 WP_002955285.1 Fic family protein Antitoxin
DOM81_RS07635 1509109..1509420 - 312 WP_014667079.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DOM81_RS07640 1509423..1509683 - 261 WP_002955287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
DOM81_RS07645 1509755..1510459 - 705 WP_002955288.1 hypothetical protein -
DOM81_RS07650 1510404..1510799 - 396 WP_002955289.1 hypothetical protein -
DOM81_RS07655 1510841..1511593 - 753 WP_014667082.1 helicase C-terminal domain-containing protein -
DOM81_RS07660 1511894..1513063 - 1170 WP_110581552.1 helicase -
DOM81_RS07665 1513095..1513553 - 459 WP_015453715.1 hypothetical protein -
DOM81_RS07670 1513781..1514152 + 372 WP_015453716.1 DUF5131 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1297747..1561855 264108


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-102)

Antitoxin

Fido domain

(74-172)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11979.07 Da        Isoelectric Point: 8.5080

>T31790 WP_014667079.1 NZ_AP018447:c1509420-1509109 [Helicobacter cinaedi]
MRQFEIFWIDLNLTKGAEISKKRPCVIISPNELNYLQTRLVAPITSKGFDAPFRVNFELEGKKSRILCDQIRCVSIDRFL
NKICDLESNKQEALKNILLEMFA

Download         Length: 312 bp

>T31790 NZ_AP018447:c1509420-1509109 [Helicobacter cinaedi]
TTGAGGCAGTTTGAGATTTTTTGGATAGATTTAAATCTTACAAAAGGAGCGGAAATTTCTAAAAAAAGACCTTGTGTGAT
TATCTCACCCAATGAATTAAACTATTTACAAACAAGACTTGTCGCGCCTATTACTTCAAAGGGATTTGATGCTCCTTTTA
GAGTAAATTTTGAATTAGAGGGCAAAAAGTCTAGAATCCTGTGCGACCAAATTCGTTGTGTGAGTATAGATAGATTCTTA
AATAAAATTTGTGATTTAGAATCTAATAAGCAAGAGGCTTTAAAAAATATTCTCCTAGAGATGTTCGCTTAA

Antitoxin


Download         Length: 241 a.a.        Molecular weight: 28290.80 Da        Isoelectric Point: 7.8535

>AT31790 WP_002955285.1 NZ_AP018447:c1509086-1508364 [Helicobacter cinaedi]
MILDNQEYMLDLCIRMAHHSTAIEGNTLTQDETASIILDNFIPRAIKDREFYEVRNYKYLLPYFIEKLKLNTKIDLELIK
FFHSFIMKDLHEEAGKFKTLENAIIGANFETAKPYLVSSLLKDMCDNLYYKLENSKNDEEKIKAILQSHIHFEKIHPFSD
GNGRIGRLLIAYSCFEHNLTPIVIPKEEKAYYISYLRANKIDDVMIDFIKKIQKEEQQRIEKFKSATLSLKNDLKPKNRK

Download         Length: 723 bp

>AT31790 NZ_AP018447:c1509086-1508364 [Helicobacter cinaedi]
ATGATATTGGACAATCAAGAATATATGCTAGATTTGTGTATAAGAATGGCTCATCACAGCACAGCAATAGAAGGTAATAC
GCTTACTCAAGATGAAACAGCCTCTATTATCCTAGATAATTTCATTCCAAGAGCAATAAAAGATAGGGAATTTTATGAAG
TAAGAAATTATAAATACCTCTTGCCTTATTTTATAGAAAAACTTAAATTAAATACAAAGATTGACTTAGAACTTATAAAG
TTTTTTCATTCTTTTATAATGAAAGATTTACACGAAGAAGCTGGGAAATTTAAAACTTTAGAAAATGCGATTATAGGTGC
AAATTTTGAAACAGCTAAACCCTATTTGGTATCCTCATTACTTAAAGATATGTGCGACAACCTATATTATAAATTAGAAA
ACTCTAAAAATGATGAGGAAAAAATTAAGGCAATTTTGCAATCCCATATTCATTTTGAGAAAATTCACCCTTTTAGTGAT
GGTAATGGGAGAATAGGTAGGCTTTTGATAGCCTATTCTTGCTTTGAACATAATTTAACGCCCATTGTTATACCTAAAGA
AGAAAAGGCTTACTATATTTCTTATTTAAGAGCAAACAAAATAGATGATGTGATGATTGATTTTATTAAAAAAATTCAAA
AGGAAGAGCAACAAAGGATAGAGAAATTTAAGTCGGCTACTTTAAGTCTTAAGAATGATTTAAAGCCAAAGAATAGAAAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References