Detailed information of TA system TA031789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 283919..284532
• Replicon: chromosome
• Accession: NZ_AP018447
• Organism: Helicobacter cinaedi strain P06D0798

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DOM81_RS01440
• Protein ID: WP_110581787.1
• Coordinates: 283919..284320 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I7HE84
• Locus tag: DOM81_RS01445
• Protein ID: WP_002957229.1
• Coordinates: 284308..284532 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOM81_RS01425	280888..282528	-	1641	Protein_273	DUF262 domain-containing protein	-
DOM81_RS11165	282538..282693	-	156	WP_165815928.1	hypothetical protein	-
DOM81_RS11170	282728..283048	-	321	WP_165815880.1	hypothetical protein	-
DOM81_RS01430	283083..283271	-	189	WP_014666336.1	hypothetical protein	-
DOM81_RS01435	283346..283717	-	372	WP_014666337.1	hypothetical protein	-
DOM81_RS01440	283919..284320	-	402	WP_110581787.1	type II toxin-antitoxin system VapC family toxin	Toxin
DOM81_RS01445	284308..284532	-	225	WP_002957229.1	hypothetical protein	Antitoxin
DOM81_RS01450	284695..285604	+	910	Protein_280	WYL domain-containing transcriptional regulator	-
DOM81_RS01455	285750..286424	+	675	WP_014666340.1	hypothetical protein	-
DOM81_RS01460	286473..287846	+	1374	WP_014666341.1	U32 family peptidase	-
DOM81_RS01465	287850..288749	-	900	WP_014667511.1	ATP-binding cassette domain-containing protein	-
DOM81_RS01470	288746..289423	-	678	WP_172580125.1	molybdate ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15206.77 Da
• Isoelectric Point: 8.4454

>T31789 WP_110581787.1 NZ_AP018447:c284320-283919 [Helicobacter cinaedi]
MAKIMLDTNICIYIINNKPQYIKDRFLQYRIGDIAISSISVAELYFGVEKSQYKEANTNALNTFLTHLKVIDFAHKEALT
YAKIRADLECKKSLIGAMDMLISAVALANDLTLITDNTKEFQRVKNLKIENWV

Nucleotide

• Length: 402 bp

>T31789 NZ_AP018447:c284320-283919 [Helicobacter cinaedi]
ATGGCAAAAATAATGCTTGATACAAATATATGTATTTATATTATCAATAATAAACCGCAATATATTAAAGATAGATTTTT
ACAATACAGAATAGGCGATATTGCTATAAGCTCTATCAGTGTAGCTGAATTATACTTTGGTGTAGAAAAATCTCAATATA
AAGAAGCAAATACAAATGCTCTTAATACATTCCTAACACACCTTAAAGTCATAGATTTCGCACATAAAGAGGCACTTACA
TATGCAAAAATTAGAGCAGATTTAGAATGCAAAAAGTCTCTCATAGGTGCTATGGATATGCTTATTTCAGCGGTAGCTCT
TGCAAATGATTTAACACTTATTACAGATAACACAAAAGAATTTCAAAGAGTTAAGAATCTAAAAATAGAAAATTGGGTGT
GA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8508.80 Da
• Isoelectric Point: 9.9129

>AT31789 WP_002957229.1 NZ_AP018447:c284532-284308 [Helicobacter cinaedi]
MKAKVFKSGNSLAIRLPKALNLTKDCEFNIKQINNNIVLTPANSNWDSLFSAIDSFKGEIKRDELILQDREWQK

Nucleotide

• Length: 225 bp

>AT31789 NZ_AP018447:c284532-284308 [Helicobacter cinaedi]
ATGAAAGCAAAAGTATTTAAAAGTGGTAATTCACTTGCGATAAGATTGCCAAAGGCATTGAATCTTACTAAGGATTGCGA
GTTTAATATAAAACAAATAAATAATAACATTGTTTTAACGCCTGCTAACTCAAATTGGGATAGTCTATTTTCAGCAATAG
ATAGCTTTAAGGGCGAAATAAAGCGAGATGAACTTATATTGCAGGATAGAGAATGGCAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A809NJV2