Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2307110..2308085 Replicon chromosome
Accession NZ_AP018443
Organism Bacillus anthracis strain CZC5

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag BAZ_RS12140 Protein ID WP_002036394.1
Coordinates 2307110..2307847 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BAZ_RS12145 Protein ID WP_000588712.1
Coordinates 2307960..2308085 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAZ_RS12120 2302838..2303620 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
BAZ_RS12125 2303742..2305427 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
BAZ_RS12130 2305534..2306016 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
BAZ_RS12135 2306184..2306921 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BAZ_RS12140 2307110..2307847 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BAZ_RS12145 2307960..2308085 + 126 WP_000588712.1 hypothetical protein Antitoxin
BAZ_RS12150 2308374..2308559 - 186 WP_002036392.1 hypothetical protein -
BAZ_RS12155 2308931..2309167 - 237 WP_001021688.1 hypothetical protein -
BAZ_RS29430 2309506..2309682 + 177 WP_000808045.1 hypothetical protein -
BAZ_RS12160 2309826..2311295 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
BAZ_RS12165 2311859..2312329 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T31786 WP_002036394.1 NZ_AP018443:2307110-2307847 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T31786 NZ_AP018443:2307110-2307847 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT31786 WP_000588712.1 NZ_AP018443:2307960-2308085 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT31786 NZ_AP018443:2307960-2308085 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References