Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 5089207..5089805 Replicon chromosome
Accession NZ_AP018439
Organism Undibacterium sp. KW1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag UNDKW_RS22900 Protein ID WP_162060619.1
Coordinates 5089455..5089805 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag UNDKW_RS22895 Protein ID WP_162060618.1
Coordinates 5089207..5089455 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UNDKW_RS22870 5084896..5085918 - 1023 WP_162060613.1 helix-turn-helix domain-containing protein -
UNDKW_RS22875 5086014..5086625 + 612 WP_162060614.1 LysE family transporter -
UNDKW_RS22880 5086707..5087804 - 1098 WP_162060615.1 MBL fold metallo-hydrolase -
UNDKW_RS22885 5088030..5088674 + 645 WP_162060616.1 TetR/AcrR family transcriptional regulator -
UNDKW_RS22890 5088696..5089094 + 399 WP_162060617.1 hypothetical protein -
UNDKW_RS22895 5089207..5089455 + 249 WP_162060618.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
UNDKW_RS22900 5089455..5089805 + 351 WP_162060619.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
UNDKW_RS22905 5089864..5090301 - 438 WP_162060620.1 hypothetical protein -
UNDKW_RS22910 5090528..5091154 - 627 WP_162060621.1 sel1 repeat family protein -
UNDKW_RS22915 5091212..5091727 - 516 WP_162060622.1 MarR family transcriptional regulator -
UNDKW_RS22920 5091932..5092813 + 882 WP_162060623.1 EamA family transporter -
UNDKW_RS22925 5092850..5093467 + 618 WP_162060624.1 nitroreductase family protein -
UNDKW_RS22930 5093483..5094196 - 714 WP_162060625.1 SDR family NAD(P)-dependent oxidoreductase -
UNDKW_RS22935 5094193..5094432 - 240 WP_162060626.1 TIGR02450 family Trp-rich protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-114)

Antitoxin

SpoVT-AbrB domain

(7-39)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12622.78 Da        Isoelectric Point: 8.5530

>T31783 WP_162060619.1 NZ_AP018439:5089455-5089805 [Undibacterium sp. KW1]
MAAYVPARGDIVHLQFDPASGHEMKGKHFGLVISQKAFNQRGLAMICPISQGAADAARTHGMIVTLMGLGLDTQGAVHCH
QMKSLDWKIRQAKFKEKVPLAIVDDVAARVEAIIFE

Download         Length: 351 bp

>T31783 NZ_AP018439:5089455-5089805 [Undibacterium sp. KW1]
ATGGCGGCATATGTTCCGGCTCGTGGTGATATCGTCCATTTACAATTTGACCCGGCATCCGGTCATGAAATGAAAGGCAA
GCATTTTGGTCTGGTGATCAGCCAAAAGGCTTTCAATCAACGTGGTCTGGCGATGATCTGCCCCATTTCCCAAGGTGCTG
CAGATGCTGCCAGGACACACGGGATGATCGTTACCCTGATGGGGTTGGGACTTGATACCCAGGGTGCAGTCCATTGTCAT
CAAATGAAATCACTGGACTGGAAAATACGTCAGGCCAAATTTAAAGAAAAAGTGCCACTGGCCATCGTTGATGATGTGGC
TGCGCGTGTTGAGGCGATTATTTTTGAGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9051.48 Da        Isoelectric Point: 4.5805

>AT31783 WP_162060618.1 NZ_AP018439:5089207-5089455 [Undibacterium sp. KW1]
MLQTLRRAGGSLVMTVPKAFIEQNQLQEGSQVELSLEGARMTVNAPSKRRYKLEELLAEMPGGELPKVEGWDEMPPAGLE
VL

Download         Length: 249 bp

>AT31783 NZ_AP018439:5089207-5089455 [Undibacterium sp. KW1]
ATGCTGCAAACATTAAGACGTGCCGGTGGCTCACTGGTGATGACGGTTCCCAAAGCGTTTATAGAACAAAACCAATTGCA
GGAAGGCTCCCAAGTAGAGCTTTCGCTGGAAGGGGCGCGCATGACTGTCAATGCACCAAGTAAGCGTCGTTACAAGCTCG
AAGAGCTGCTGGCAGAAATGCCGGGCGGGGAACTGCCAAAAGTAGAAGGCTGGGATGAAATGCCTCCCGCCGGATTGGAA
GTTCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References