Detailed information of TA system TA031773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 824389..824887
• Replicon: chromosome
• Accession: NZ_AP018391
• Organism: Streptococcus pneumoniae strain MDRSPN001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MDRSPN_RS04305
• Protein ID: WP_001812387.1
• Coordinates: 824633..824887 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: MDRSPN_RS04300
• Protein ID: WP_000208080.1
• Coordinates: 824389..824631 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MDRSPN_RS04280	820211..821386	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
MDRSPN_RS04285	821441..822145	+	705	WP_000722076.1	response regulator transcription factor	-
MDRSPN_RS04290	822138..823487	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
MDRSPN_RS04295	823489..824298	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
MDRSPN_RS04300	824389..824631	+	243	WP_000208080.1	hypothetical protein	Antitoxin
MDRSPN_RS04305	824633..824887	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MDRSPN_RS04310	824934..825707	+	774	WP_000731129.1	ion transporter	-
MDRSPN_RS04315	826023..827369	-	1347	WP_001814919.1	IS1380-like element ISSpn5 family transposase	-
MDRSPN_RS04320	827678..828664	-	987	WP_000204727.1	L-lactate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	826023..827369	1346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T31773 WP_001812387.1 NZ_AP018391:824633-824887 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T31773 NZ_AP018391:824633-824887 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT31773 WP_000208080.1 NZ_AP018391:824389-824631 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT31773 NZ_AP018391:824389-824631 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7