Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 946385..947040 Replicon chromosome
Accession NZ_AP018377
Organism Neisseria gonorrhoeae strain FC428

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag EP178_RS05505 Protein ID WP_003691083.1
Coordinates 946385..946804 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag EP178_RS05510 Protein ID WP_003688410.1
Coordinates 946804..947040 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP178_RS05485 941619..943160 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
EP178_RS05490 943308..944087 + 780 WP_003688416.1 (Fe-S)-binding protein -
EP178_RS05495 944084..944785 + 702 WP_003688414.1 lactate utilization protein C -
EP178_RS05500 944782..946236 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
EP178_RS05505 946385..946804 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
EP178_RS05510 946804..947040 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
EP178_RS05515 947246..947443 - 198 WP_033910354.1 IS3 family transposase -
EP178_RS05520 947488..948066 - 579 WP_003688041.1 IS3 family transposase -
EP178_RS05525 948071..948499 - 429 WP_010360042.1 helix-turn-helix domain-containing protein -
EP178_RS05530 948711..949097 + 387 Protein_951 IS110 family transposase -
EP178_RS05535 949480..950370 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
EP178_RS05540 950381..951547 - 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
EP178_RS05545 951619..951906 - 288 WP_025455945.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T31767 WP_003691083.1 NZ_AP018377:c946804-946385 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T31767 NZ_AP018377:c946804-946385 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT31767 WP_003688410.1 NZ_AP018377:c947040-946804 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT31767 NZ_AP018377:c947040-946804 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References