31759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2224707..2225221 Replicon chromosome
Accession NZ_AP018349
Organism Staphylococcus aureus strain GN1

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag D8S83_RS11300 Protein ID WP_000581792.1
Coordinates 2224707..2224916 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag D8S83_RS11305 Protein ID WP_000138934.1
Coordinates 2224928..2225221 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8S83_RS11280 2220214..2221572 - 1359 WP_000611467.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
D8S83_RS11285 2221587..2222657 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
D8S83_RS11290 2222975..2224177 + 1203 WP_001109939.1 rod shape-determining protein RodA -
D8S83_RS11295 2224441..2224578 - 138 WP_000828354.1 hypothetical protein -
D8S83_RS11300 2224707..2224916 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
D8S83_RS11305 2224928..2225221 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
D8S83_RS11310 2225387..2226871 + 1485 WP_020977447.1 cardiolipin synthase -
D8S83_RS11315 2226899..2227546 + 648 WP_001187619.1 HD domain-containing protein -
D8S83_RS11340 2228360..2229232 - 873 WP_000725802.1 membrane protein insertase YidC -
D8S83_RS11345 2229318..2229959 - 642 WP_000483165.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T31759 WP_000581792.1 NZ_AP018349:c2224916-2224707 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T31759 NZ_AP018349:c2224916-2224707 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT31759 WP_000138934.1 NZ_AP018349:c2225221-2224928 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT31759 NZ_AP018349:c2225221-2224928 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References