Detailed information of TA system TA031757

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2151147..2151679
• Replicon: chromosome
• Accession: NZ_AP018349
• Organism: Staphylococcus aureus strain GN1

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q8VLW9
• Locus tag: D8S83_RS10915
• Protein ID: WP_001103944.1
• Coordinates: 2151147..2151467 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: D8S83_RS10920
• Protein ID: WP_001058486.1
• Coordinates: 2151470..2151679 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8S83_RS10895	2147149..2147790	-	642	WP_020977425.1	mobile element-associated protein	-
D8S83_RS10900	2147787..2148167	-	381	WP_020977426.1	hypothetical protein	-
D8S83_RS10905	2148497..2150197	-	1701	WP_000447470.1	DUF927 domain-containing protein	-
D8S83_RS10910	2150211..2151080	-	870	WP_086114945.1	primase alpha helix C-terminal domain-containing protein	-
D8S83_RS10915	2151147..2151467	-	321	WP_001103944.1	DUF1474 family protein	Toxin
D8S83_RS10920	2151470..2151679	-	210	WP_001058486.1	hypothetical protein	Antitoxin
D8S83_RS10925	2151672..2151818	-	147	WP_000708434.1	hypothetical protein	-
D8S83_RS10930	2151815..2152132	-	318	WP_020977427.1	helix-turn-helix domain-containing protein	-
D8S83_RS10935	2152137..2152355	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
D8S83_RS10940	2152528..2153202	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
D8S83_RS10945	2153216..2154388	+	1173	WP_000179346.1	site-specific integrase	-
D8S83_RS10950	2154457..2156073	-	1617	WP_120173204.1	chaperonin GroEL	-
D8S83_RS10955	2156149..2156433	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2138354..2156433	18079

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.31 Da
• Isoelectric Point: 4.8519

>T31757 WP_001103944.1 NZ_AP018349:c2151467-2151147 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKKLKITE

Nucleotide

• Length: 321 bp

>T31757 NZ_AP018349:c2151467-2151147 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT31757 WP_001058486.1 NZ_AP018349:c2151679-2151470 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT31757 NZ_AP018349:c2151679-2151470 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q8VLW9