Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 936959..937436 Replicon chromosome
Accession NZ_AP018349
Organism Staphylococcus aureus strain GN1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag D8S83_RS04595 Protein ID WP_000052076.1
Coordinates 936959..937147 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag D8S83_RS04600 Protein ID WP_001059690.1
Coordinates 937176..937436 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8S83_RS04565 932995..933467 + 473 Protein_845 hypothetical protein -
D8S83_RS04570 933808..934494 + 687 WP_001641381.1 thermonuclease family protein -
D8S83_RS04575 934851..935051 + 201 WP_001059082.1 cold-shock protein -
D8S83_RS04580 935549..935767 - 219 WP_000005880.1 hypothetical protein -
D8S83_RS04585 935830..936114 - 285 WP_001004401.1 hypothetical protein -
D8S83_RS04590 936202..936771 - 570 WP_020977093.1 hypothetical protein -
D8S83_RS04595 936959..937147 - 189 WP_000052076.1 hypothetical protein Toxin
D8S83_RS04600 937176..937436 - 261 WP_001059690.1 hypothetical protein Antitoxin
D8S83_RS04605 937776..937979 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
D8S83_RS04610 937976..938212 - 237 WP_000368687.1 hypothetical protein -
D8S83_RS04615 938437..939018 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
D8S83_RS04620 939091..939708 - 618 WP_020977094.1 LysE/ArgO family amino acid transporter -
D8S83_RS04625 940001..940495 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
D8S83_RS04630 940894..941316 - 423 WP_020977095.1 organic hydroperoxide resistance protein -
D8S83_RS04635 941464..942180 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T31750 WP_000052076.1 NZ_AP018349:c937147-936959 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T31750 NZ_AP018349:c937147-936959 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT31750 WP_001059690.1 NZ_AP018349:c937436-937176 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT31750 NZ_AP018349:c937436-937176 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References