Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 747725..748971 Replicon chromosome
Accession NZ_AP018338
Organism Streptococcus oralis subsp. tigurinus strain osk_001

Toxin (Protein)


Gene name zeta Uniprot ID A0A224A678
Locus tag STO1_RS03810 Protein ID WP_045773572.1
Coordinates 748201..748971 (+) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A224A711
Locus tag STO1_RS03805 Protein ID WP_045773571.1
Coordinates 747725..748201 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STO1_RS03765 743979..744263 + 285 WP_096422009.1 hypothetical protein -
STO1_RS03770 744277..744573 + 297 WP_096422011.1 hypothetical protein -
STO1_RS03775 744587..744784 - 198 WP_096422013.1 hypothetical protein -
STO1_RS03780 744944..745585 + 642 WP_096422015.1 peptidylprolyl isomerase -
STO1_RS03785 745595..746680 + 1086 WP_000510561.1 toprim domain-containing protein -
STO1_RS03790 746731..746964 + 234 WP_000152419.1 hypothetical protein -
STO1_RS03795 746961..747344 + 384 WP_096422017.1 chemotaxis protein -
STO1_RS03800 747382..747654 + 273 WP_045773570.1 hypothetical protein -
STO1_RS03805 747725..748201 + 477 WP_045773571.1 helix-turn-helix domain-containing protein Antitoxin
STO1_RS03810 748201..748971 + 771 WP_045773572.1 zeta toxin family protein Toxin
STO1_RS03815 749226..749909 + 684 WP_045773573.1 LexA family transcriptional regulator -
STO1_RS03820 749912..751327 + 1416 WP_045773574.1 Y-family DNA polymerase -
STO1_RS03825 751324..751689 + 366 WP_045773575.1 hypothetical protein -
STO1_RS03830 751679..751969 + 291 WP_001080186.1 hypothetical protein -
STO1_RS03835 752261..752617 + 357 WP_001115082.1 hypothetical protein -
STO1_RS03840 752622..752987 + 366 WP_037612713.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element mef(A) / msr(D) / tet(M) - 662732..778701 115969


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(24-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29294.25 Da        Isoelectric Point: 8.4067

>T31746 WP_045773572.1 NZ_AP018338:748201-748971 [Streptococcus oralis subsp. tigurinus]
MEIQDYTDSEFKHALERNIRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTVDVPNKTAKLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVNNTRQLEELAIFERIQIYQRDRSCVYDSRENTTSAATVLQDLLFGEWSQVEKEML
KSGEERLKDLTNRNGC

Download         Length: 771 bp

>T31746 NZ_AP018338:748201-748971 [Streptococcus oralis subsp. tigurinus]
ATGGAAATCCAAGATTATACCGATAGTGAATTCAAACATGCTTTAGAGCGGAACATTCGCTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGCGTTGAATACACCAAAGATTTCGCAGGGAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATAGAAGGAACTTTACGAACAGTTGATGTTCCAAATAAAACAGCAAAACTCTTGAAAAATA
AGGGGTATGAGGTACAATTAGCCTTAATTGCAACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTATACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTAATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCGA
GAGAAAATACAACTTCAGCAGCAACAGTTCTTCAGGATTTACTGTTTGGGGAGTGGAGTCAGGTCGAGAAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATCGAAATGGTTGTTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18208.58 Da        Isoelectric Point: 4.3571

>AT31746 WP_045773571.1 NZ_AP018338:747725-748201 [Streptococcus oralis subsp. tigurinus]
MIGKNIKSLRKTHDLTQDDFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTSIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT31746 NZ_AP018338:747725-748201 [Streptococcus oralis subsp. tigurinus]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAAGACGACTTTGCCCGAATTGTAGGAATTTC
TCGAAATAGCTTGAGCCGGTATGAAAATGGAACGAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGCTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAGTATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGTTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A224A678

Antitoxin

Source ID Structure
AlphaFold DB A0A224A711

References