Detailed information of TA system TA031744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1673253..1673865
• Replicon: chromosome
• Accession: NZ_AP018337
• Organism: Streptococcus pyogenes strain KS030

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: SPYKS030_RS08900
• Protein ID: WP_002982731.1
• Coordinates: 1673530..1673865 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A5S4TJ53
• Locus tag: SPYKS030_RS08895
• Protein ID: WP_011055007.1
• Coordinates: 1673253..1673540 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPYKS030_RS08870	1668445..1669428	-	984	WP_011055003.1	tagatose-bisphosphate aldolase	-
SPYKS030_RS08875	1669432..1670361	-	930	WP_011055004.1	tagatose-6-phosphate kinase	-
SPYKS030_RS08880	1670407..1670922	-	516	WP_011055005.1	galactose-6-phosphate isomerase subunit LacB	-
SPYKS030_RS08885	1670957..1671385	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
SPYKS030_RS08890	1671830..1672603	+	774	WP_011055006.1	DeoR/GlpR family DNA-binding transcription regulator	-
SPYKS030_RS08895	1673253..1673540	+	288	WP_011055007.1	hypothetical protein	Antitoxin
SPYKS030_RS08900	1673530..1673865	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPYKS030_RS10140	1673932..1675003	+	1072	Protein_1651	site-specific integrase	-
SPYKS030_RS08925	1675135..1675527	-	393	WP_002982716.1	30S ribosomal protein S9	-
SPYKS030_RS08930	1675548..1675994	-	447	WP_002982710.1	50S ribosomal protein L13	-
SPYKS030_RS08935	1676212..1676418	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
SPYKS030_RS08940	1676415..1677113	-	699	WP_011055008.1	hypothetical protein	-
SPYKS030_RS08945	1677240..1678100	-	861	WP_011055009.1	DegV family protein	-
SPYKS030_RS08950	1678197..1678715	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T31744 WP_002982731.1 NZ_AP018337:1673530-1673865 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T31744 NZ_AP018337:1673530-1673865 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10964.59 Da
• Isoelectric Point: 5.2318

>AT31744 WP_011055007.1 NZ_AP018337:1673253-1673540 [Streptococcus pyogenes]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT31744 NZ_AP018337:1673253-1673540 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAACGGTTACCTTTCAAGCTAATAAAGAACTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A5S4TJ53