Detailed information of TA system TA031742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1243120..1243814
• Replicon: chromosome
• Accession: NZ_AP018335
• Organism: Ureibacillus thermosphaericus strain A1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: UtA1_RS06025
• Protein ID: WP_096550369.1
• Coordinates: 1243428..1243814 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: UtA1_RS06020
• Protein ID: WP_096552427.1
• Coordinates: 1243120..1243428 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UtA1_RS06000	1238219..1239097	-	879	WP_096550367.1	UTP--glucose-1-phosphate uridylyltransferase GalU	-
UtA1_RS06005	1239362..1240354	+	993	WP_096552425.1	UDP-glucose 4-epimerase GalE	-
UtA1_RS17445	1240542..1241153	-	612	WP_197722749.1	transposase	-
UtA1_RS17450	1241098..1241604	-	507	WP_197722761.1	transposase	-
UtA1_RS17455	1241606..1241815	-	210	WP_197722750.1	hypothetical protein	-
UtA1_RS06015	1242524..1242766	+	243	WP_096550368.1	hypothetical protein	-
UtA1_RS06020	1243120..1243428	+	309	WP_096552427.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
UtA1_RS06025	1243428..1243814	+	387	WP_096550369.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
UtA1_RS06030	1244131..1244739	+	609	WP_096550370.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
UtA1_RS06035	1244739..1245650	+	912	WP_096550371.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
UtA1_RS06040	1245705..1246391	+	687	WP_096550372.1	hypothetical protein	-
UtA1_RS17460	1246530..1246733	-	204	WP_197722751.1	transposase	-
UtA1_RS17465	1246827..1247456	-	630	WP_197722752.1	transposase	-
UtA1_RS17470	1247469..1247768	-	300	WP_197722753.1	transposase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-116)

Antitoxin

• Antitoxin PemI-like (24-100)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14297.24 Da
• Isoelectric Point: 4.6190

>T31742 WP_096550369.1 NZ_AP018335:1243428-1243814 [Ureibacillus thermosphaericus]
MPADVPERGDFVVLNFNSQAGHEQAGRRNAIVLSPKEFNQATGFIAVCPITNQKKGYPFEVDLPKEGISPDGDGYPITGV
VLTDQIKSFDWKARNLKILKKYNPEDAQIEEIDKIIDECLAKIETYLT

Nucleotide

• Length: 387 bp

>T31742 NZ_AP018335:1243428-1243814 [Ureibacillus thermosphaericus]
ATGCCAGCAGACGTACCAGAGAGAGGCGATTTCGTTGTTTTAAACTTCAATTCACAAGCTGGTCATGAGCAGGCTGGGAG
AAGAAATGCTATTGTTTTATCGCCTAAAGAATTCAATCAAGCAACAGGATTTATAGCTGTTTGTCCGATTACCAATCAAA
AGAAGGGTTATCCCTTCGAAGTGGATTTACCAAAAGAAGGAATATCCCCTGATGGCGATGGCTATCCAATAACAGGGGTA
GTTTTAACTGATCAAATTAAATCATTCGATTGGAAAGCTCGTAATCTAAAAATTTTAAAGAAGTATAATCCAGAAGATGC
ACAAATTGAAGAAATAGATAAAATCATTGATGAATGCCTAGCGAAAATAGAAACATATCTGACTTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11509.13 Da
• Isoelectric Point: 6.4776

>AT31742 WP_096552427.1 NZ_AP018335:1243120-1243428 [Ureibacillus thermosphaericus]
MNSKEHLESKINQSKGGDYMSTVVAQKWGNSLGIRIPKDIADKIGIKQGSEMELNVIGNEGIITLKPKRTRTKYTLEELI
SQITPENRHEEIDFGIEGRELI

Nucleotide

• Length: 309 bp

>AT31742 NZ_AP018335:1243120-1243428 [Ureibacillus thermosphaericus]
ATGAACTCAAAGGAACATTTAGAAAGCAAAATAAACCAAAGTAAAGGAGGGGACTACATGTCTACAGTTGTTGCTCAAAA
ATGGGGAAACAGTTTGGGCATTCGTATCCCAAAAGATATTGCTGATAAAATAGGGATTAAACAAGGTTCCGAAATGGAAT
TAAATGTGATTGGAAATGAAGGTATCATCACATTGAAGCCAAAAAGAACACGGACGAAATACACACTGGAAGAATTAATA
TCACAGATTACACCTGAAAATCGACACGAGGAAATTGATTTCGGGATAGAAGGGCGTGAATTGATTTAA