Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 267410..268050 Replicon chromosome
Accession NZ_AP018335
Organism Ureibacillus thermosphaericus strain A1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag UtA1_RS01295 Protein ID WP_096549791.1
Coordinates 267410..267760 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag UtA1_RS01300 Protein ID WP_096549792.1
Coordinates 267766..268050 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UtA1_RS01270 264035..264817 - 783 WP_096549788.1 RNA polymerase sigma factor SigB -
UtA1_RS01275 264792..265265 - 474 WP_096549789.1 anti-sigma B factor RsbW -
UtA1_RS01280 265252..265596 - 345 WP_016838303.1 STAS domain-containing protein -
UtA1_RS01285 265671..266669 - 999 WP_016838304.1 PP2C family protein-serine/threonine phosphatase -
UtA1_RS01290 266684..267085 - 402 WP_096549790.1 anti-sigma regulatory factor -
UtA1_RS01295 267410..267760 - 351 WP_096549791.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
UtA1_RS01300 267766..268050 - 285 WP_096549792.1 transcriptional regulator Antitoxin
UtA1_RS01305 268185..269306 - 1122 WP_096549793.1 alanine racemase -
UtA1_RS01310 269399..270406 - 1008 WP_096549794.1 outer membrane lipoprotein carrier protein LolA -
UtA1_RS01315 270508..270864 - 357 WP_016838310.1 holo-ACP synthase -
UtA1_RS01320 270935..271540 + 606 WP_016838311.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12959.09 Da        Isoelectric Point: 5.7348

>T31741 WP_096549791.1 NZ_AP018335:c267760-267410 [Ureibacillus thermosphaericus]
MIVKRGDVFFADLSPVVGSEQGGTRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQL
RTIDKSRLTDRITHLDDELMEKVDIALEISLGLIKF

Download         Length: 351 bp

>T31741 NZ_AP018335:c267760-267410 [Ureibacillus thermosphaericus]
TTGATTGTAAAACGTGGGGACGTTTTCTTCGCAGACTTGTCGCCTGTTGTAGGTTCTGAACAGGGCGGTACAAGGCCTGT
GTTAATTATCCAAAATGATATTGGGAATCGATTTAGTCCTACTGTGATTATTGCTGCAATTACTGCGCAAATTCAAAAAG
CAAAATTACCTACCCATGTCGAAATAGATGCGAAAAAATATGGATTCGAAAGGGACTCGGTAATTTTGCTTGAACAATTG
CGCACTATAGATAAGTCCAGATTAACCGACCGAATAACCCATCTGGACGATGAGCTGATGGAAAAAGTCGATATCGCTTT
GGAAATAAGTTTAGGTTTAATAAAATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10676.27 Da        Isoelectric Point: 6.4489

>AT31741 WP_096549792.1 NZ_AP018335:c268050-267766 [Ureibacillus thermosphaericus]
VYAKKVNGAKEVKVALPQEMVMEFCGGNLEYSNNEMFIFTFKRREAACKQPNQIREALRKGYVEMAQINLSISCECLHAE
YEAEHTVERLVSGG

Download         Length: 285 bp

>AT31741 NZ_AP018335:c268050-267766 [Ureibacillus thermosphaericus]
GTGTACGCAAAAAAAGTGAATGGTGCAAAGGAAGTAAAGGTGGCTCTTCCTCAGGAAATGGTCATGGAATTTTGCGGTGG
AAATTTAGAATATTCGAATAATGAAATGTTTATTTTTACGTTTAAAAGAAGAGAAGCTGCGTGCAAGCAACCAAATCAAA
TACGGGAAGCTTTGAGAAAAGGCTATGTAGAAATGGCTCAAATTAATTTGTCGATTTCATGTGAATGTCTACATGCCGAG
TATGAAGCAGAACATACAGTGGAGCGTCTCGTAAGCGGGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References