Detailed information of TA system TA031740

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 1141772..1142217
• Replicon: chromosome
• Accession: NZ_AP018281
• Organism: Chondrocystis sp. NIES-4102

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CDC35_RS04920
• Protein ID: WP_096718648.1
• Coordinates: 1141772..1141996 (-)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CDC35_RS04925
• Protein ID: WP_096718650.1
• Coordinates: 1141993..1142217 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDC35_RS04890	1138033..1138152	-	120	WP_096718636.1	photosystem II reaction center X protein	-
CDC35_RS04895	1138315..1138605	+	291	WP_096718638.1	YggT family protein	-
CDC35_RS04900	1138602..1139951	-	1350	WP_096718640.1	acetyl-CoA carboxylase biotin carboxylase subunit	-
CDC35_RS04905	1140020..1140289	-	270	WP_096718642.1	hypothetical protein	-
CDC35_RS04910	1140832..1141107	+	276	WP_096718644.1	hypothetical protein	-
CDC35_RS04915	1141128..1141586	+	459	WP_096718646.1	PPC domain-containing protein	-
CDC35_RS04920	1141772..1141996	-	225	WP_096718648.1	type II toxin-antitoxin system HicA family toxin	Toxin
CDC35_RS04925	1141993..1142217	-	225	WP_096718650.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CDC35_RS04930	1142403..1142960	-	558	WP_096718652.1	hypothetical protein	-
CDC35_RS04935	1143126..1146869	-	3744	WP_096718654.1	magnesium chelatase subunit H	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-63)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (14-66)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8431.04 Da
• Isoelectric Point: 10.5957

>T31740 WP_096718648.1 NZ_AP018281:c1141996-1141772 [Chondrocystis sp. NIES-4102]
MSKLPVISGTECIKGLEKIGFKIIRQRGSHLVLIRENPITTVIVPNHKELDRGTLRAIIRQVDLTVDEFIQLLR

Nucleotide

• Length: 225 bp

>T31740 NZ_AP018281:c1141996-1141772 [Chondrocystis sp. NIES-4102]
ATGAGCAAACTACCCGTTATTTCTGGCACAGAATGTATTAAAGGGTTAGAAAAAATTGGCTTTAAAATTATTAGACAACG
AGGAAGTCATCTAGTTTTAATCAGAGAAAATCCTATAACTACCGTAATCGTCCCAAATCACAAGGAGTTAGATAGAGGTA
CTTTACGCGCTATTATTCGGCAAGTTGATTTAACTGTAGATGAGTTTATTCAACTTTTAAGATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8234.47 Da
• Isoelectric Point: 4.2845

>AT31740 WP_096718650.1 NZ_AP018281:c1142217-1141993 [Chondrocystis sp. NIES-4102]
MTTKIKSQQRKVLLYPGEDGYFVVEVPSLPGCISQGKTREEALANIEEAIALYVEVLQERGDSVPKDEVEVILI

Nucleotide

• Length: 225 bp

>AT31740 NZ_AP018281:c1142217-1141993 [Chondrocystis sp. NIES-4102]
ATGACTACTAAAATTAAATCCCAACAACGCAAAGTGCTTCTATATCCTGGTGAAGACGGTTACTTTGTAGTAGAAGTACC
CAGCTTACCTGGTTGTATTAGTCAGGGAAAAACTCGTGAAGAAGCTTTAGCCAATATAGAAGAAGCGATCGCTCTTTATG
TAGAAGTTTTGCAAGAAAGAGGGGACAGCGTTCCTAAAGATGAAGTAGAAGTTATCTTAATATGA