Detailed information of TA system TA031725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 837599..838139
• Replicon: chromosome
• Accession: NZ_AP018255
• Organism: Calothrix sp. NIES-4071

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CDC41_RS03270
• Protein ID: WP_096684279.1
• Coordinates: 837861..838139 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CDC41_RS03265
• Protein ID: WP_096684278.1
• Coordinates: 837599..837871 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDC41_RS03245	833184..833771	-	588	WP_096684274.1	hypothetical protein	-
CDC41_RS03250	833764..835449	-	1686	WP_096684275.1	ATP-binding protein	-
CDC41_RS03255	835464..836621	-	1158	WP_096684276.1	hypothetical protein	-
CDC41_RS03260	836618..837439	-	822	WP_096684277.1	hypothetical protein	-
CDC41_RS03265	837599..837871	+	273	WP_096684278.1	CopG family ribbon-helix-helix protein	Antitoxin
CDC41_RS03270	837861..838139	+	279	WP_096684279.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDC41_RS03275	838161..842423	-	4263	WP_096684280.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (4-41)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10632.34 Da
• Isoelectric Point: 8.4538

>T31725 WP_096684279.1 NZ_AP018255:837861-838139 [Calothrix sp. NIES-4071]
MEIKFSASAIQDLIRLRKFIAVNNPSAAKRMSLRLQQAIGKLANYPDIGRLVEELEGVRELVAGNYIVRYLPSDEEIFVL
RIWHGKEYRDLD

Nucleotide

• Length: 279 bp

>T31725 NZ_AP018255:837861-838139 [Calothrix sp. NIES-4071]
ATGGAGATTAAATTTTCGGCAAGTGCTATACAAGATTTGATTCGTTTACGAAAATTTATTGCTGTTAATAATCCATCAGC
CGCAAAGCGAATGTCGCTTCGATTACAACAAGCGATTGGAAAGCTTGCAAATTATCCTGATATCGGGCGCCTCGTTGAAG
AACTTGAAGGTGTACGCGAATTAGTCGCGGGAAATTACATAGTTAGGTATCTACCTAGTGACGAAGAAATTTTTGTGCTA
CGAATTTGGCACGGTAAGGAATATCGGGATTTAGATTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10376.57 Da
• Isoelectric Point: 4.3272

>AT31725 WP_096684278.1 NZ_AP018255:837599-837871 [Calothrix sp. NIES-4071]
MSTTSFRLDEDLQEKLDSTAVRLKRTKGWLINEAVRQYIEREELRDKMLSETEEAIADIEAGRIVSGEEVLNWLKTWGTE
AESKAPQYGD

Nucleotide

• Length: 273 bp

>AT31725 NZ_AP018255:837599-837871 [Calothrix sp. NIES-4071]
ATGAGTACTACAAGCTTTCGGTTGGATGAAGACTTACAGGAAAAGCTGGATAGCACTGCCGTGCGGCTCAAGCGAACCAA
AGGTTGGTTAATTAATGAAGCAGTACGCCAGTATATCGAACGCGAAGAACTTAGAGATAAGATGTTGTCCGAAACAGAAG
AAGCTATCGCCGATATTGAAGCTGGGCGTATTGTTTCTGGAGAAGAGGTGTTGAACTGGCTAAAGACTTGGGGAACCGAA
GCAGAAAGTAAGGCGCCTCAATATGGAGATTAA