Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-UPF0150 |
Location | 3436074..3436504 | Replicon | chromosome |
Accession | NZ_AP018254 | ||
Organism | Calothrix sp. NIES-3974 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | CDC37_RS13815 | Protein ID | WP_096622537.1 |
Coordinates | 3436074..3436298 (-) | Length | 75 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | G6FUJ8 |
Locus tag | CDC37_RS13820 | Protein ID | WP_009457224.1 |
Coordinates | 3436298..3436504 (-) | Length | 69 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CDC37_RS13800 | 3431789..3432964 | + | 1176 | WP_096622536.1 | IscS subfamily cysteine desulfurase | - |
CDC37_RS13805 | 3434000..3434806 | + | 807 | WP_096626213.1 | Nif3-like dinuclear metal center hexameric protein | - |
CDC37_RS13810 | 3435006..3435285 | - | 280 | Protein_2736 | hypothetical protein | - |
CDC37_RS13815 | 3436074..3436298 | - | 225 | WP_096622537.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
CDC37_RS13820 | 3436298..3436504 | - | 207 | WP_009457224.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
CDC37_RS13825 | 3436595..3436978 | - | 384 | WP_096622538.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
CDC37_RS13830 | 3436978..3437175 | - | 198 | WP_096622539.1 | DNA-binding protein | - |
CDC37_RS13835 | 3437725..3438255 | - | 531 | WP_096622540.1 | GNAT family N-acetyltransferase | - |
CDC37_RS24350 | 3438281..3438418 | - | 138 | WP_157780748.1 | hypothetical protein | - |
CDC37_RS13840 | 3438498..3438827 | - | 330 | WP_096622541.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
CDC37_RS13845 | 3438805..3439008 | - | 204 | WP_096622542.1 | antitoxin family protein | - |
CDC37_RS13855 | 3439526..3439744 | + | 219 | WP_096622543.1 | DUF433 domain-containing protein | - |
CDC37_RS13860 | 3439746..3440069 | + | 324 | Protein_2746 | DUF5615 family PIN-like protein | - |
CDC37_RS13865 | 3440092..3440505 | - | 414 | WP_096622544.1 | GIY-YIG nuclease family protein | - |
CDC37_RS13870 | 3440667..3441311 | - | 645 | WP_096622545.1 | NADPH-dependent F420 reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 75 a.a. Molecular weight: 8108.39 Da Isoelectric Point: 6.4628
>T31723 WP_096622537.1 NZ_AP018254:c3436298-3436074 [Calothrix sp. NIES-3974]
MGSALPVMSGREVVRVFESLGWEAVRQTGSHIIMTKDEELVTLSIPDHREVAKGTLRSLIRTAGLTVEEFVAAK
MGSALPVMSGREVVRVFESLGWEAVRQTGSHIIMTKDEELVTLSIPDHREVAKGTLRSLIRTAGLTVEEFVAAK
Download Length: 225 bp
>T31723 NZ_AP018254:c3436298-3436074 [Calothrix sp. NIES-3974]
ATGGGTTCTGCTTTACCTGTCATGAGTGGGCGCGAAGTCGTGCGCGTCTTTGAGTCGTTAGGTTGGGAGGCTGTACGGCA
GACGGGTAGCCACATCATTATGACGAAGGACGAGGAGCTTGTCACACTTTCAATTCCTGATCACCGTGAAGTAGCAAAAG
GAACTTTAAGAAGTTTGATTCGCACTGCTGGATTAACCGTAGAGGAATTTGTTGCTGCTAAATAG
ATGGGTTCTGCTTTACCTGTCATGAGTGGGCGCGAAGTCGTGCGCGTCTTTGAGTCGTTAGGTTGGGAGGCTGTACGGCA
GACGGGTAGCCACATCATTATGACGAAGGACGAGGAGCTTGTCACACTTTCAATTCCTGATCACCGTGAAGTAGCAAAAG
GAACTTTAAGAAGTTTGATTCGCACTGCTGGATTAACCGTAGAGGAATTTGTTGCTGCTAAATAG
Antitoxin
Download Length: 69 a.a. Molecular weight: 7495.56 Da Isoelectric Point: 4.1435
>AT31723 WP_009457224.1 NZ_AP018254:c3436504-3436298 [Calothrix sp. NIES-3974]
MRFSVTLDRDEDGIWVVECPSIPGCVSQGQTKQEALENIKDAIAACLQVRAERGMPLTVETYQVEVVA
MRFSVTLDRDEDGIWVVECPSIPGCVSQGQTKQEALENIKDAIAACLQVRAERGMPLTVETYQVEVVA
Download Length: 207 bp
>AT31723 NZ_AP018254:c3436504-3436298 [Calothrix sp. NIES-3974]
ATGAGATTTAGTGTAACGCTCGATCGCGATGAGGATGGAATTTGGGTTGTAGAGTGTCCTAGCATTCCGGGATGTGTGAG
TCAAGGTCAGACGAAACAGGAAGCCCTTGAAAATATCAAAGATGCGATCGCAGCGTGTCTACAGGTTCGGGCAGAGCGTG
GAATGCCGCTGACAGTAGAAACCTATCAGGTTGAGGTCGTTGCCTAA
ATGAGATTTAGTGTAACGCTCGATCGCGATGAGGATGGAATTTGGGTTGTAGAGTGTCCTAGCATTCCGGGATGTGTGAG
TCAAGGTCAGACGAAACAGGAAGCCCTTGAAAATATCAAAGATGCGATCGCAGCGTGTCTACAGGTTCGGGCAGAGCGTG
GAATGCCGCTGACAGTAGAAACCTATCAGGTTGAGGTCGTTGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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