Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3426458..3427095 Replicon chromosome
Accession NZ_AP018254
Organism Calothrix sp. NIES-3974

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDC37_RS13775 Protein ID WP_096622532.1
Coordinates 3426458..3426853 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDC37_RS13780 Protein ID WP_096622533.1
Coordinates 3426850..3427095 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDC37_RS13735 3421606..3422514 + 909 WP_096622526.1 carotenoid biosynthesis protein -
CDC37_RS13740 3422661..3422921 + 261 WP_096622527.1 hypothetical protein -
CDC37_RS13745 3422924..3423970 - 1047 WP_096626211.1 aspartate carbamoyltransferase catalytic subunit -
CDC37_RS13750 3424040..3424240 + 201 WP_096622528.1 DUF3291 domain-containing protein -
CDC37_RS13755 3424300..3424648 + 349 Protein_2726 DUF433 domain-containing protein -
CDC37_RS13760 3424945..3425178 + 234 WP_096622529.1 DUF433 domain-containing protein -
CDC37_RS13765 3425175..3425561 + 387 WP_096622530.1 DUF5615 family PIN-like protein -
CDC37_RS13775 3426458..3426853 - 396 WP_096622532.1 type II toxin-antitoxin system VapC family toxin Toxin
CDC37_RS13780 3426850..3427095 - 246 WP_096622533.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CDC37_RS13785 3427839..3428162 + 324 WP_096622534.1 hypothetical protein -
CDC37_RS13790 3428961..3430304 - 1344 WP_096622535.1 magnesium transporter -
CDC37_RS13795 3430803..3431199 + 397 Protein_2733 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14979.35 Da        Isoelectric Point: 5.1404

>T31722 WP_096622532.1 NZ_AP018254:c3426853-3426458 [Calothrix sp. NIES-3974]
VRLLLDTQCWLWWFAQPEKLNENVIEQIVDETNEVWLSVASVWEMGIKVSIGKLPLPKQIDDYVSTRMTQLGARSLEITA
SHALRVAALPLHHRDPFDRMLIAQAQVEDMTLVSADSTFKQYKVCLLWAAS

Download         Length: 396 bp

>T31722 NZ_AP018254:c3426853-3426458 [Calothrix sp. NIES-3974]
GTGAGACTTTTGCTGGATACACAATGCTGGTTATGGTGGTTTGCTCAACCAGAAAAGTTAAATGAGAACGTGATTGAGCA
AATTGTGGATGAAACCAATGAAGTATGGTTATCAGTTGCCAGTGTTTGGGAGATGGGAATTAAAGTTTCCATTGGTAAGC
TGCCACTGCCAAAGCAAATAGATGATTATGTCTCTACTCGCATGACTCAACTAGGAGCTAGATCGTTAGAAATCACCGCT
TCTCATGCTTTGCGGGTGGCTGCATTACCTTTACATCATCGTGACCCTTTTGACAGAATGCTAATTGCCCAAGCTCAGGT
AGAAGACATGACACTTGTGAGTGCAGATTCAACATTTAAGCAATATAAAGTCTGTTTACTCTGGGCAGCTAGCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8947.14 Da        Isoelectric Point: 4.7361

>AT31722 WP_096622533.1 NZ_AP018254:c3427095-3426850 [Calothrix sp. NIES-3974]
METVNIHQAKTNLSRLLSRVEQGEEIVISNRGIPIAKLVPFRTSLDRRSSLGQDRGLFTVPDDFNAPLPEDILVAFEGGA
E

Download         Length: 246 bp

>AT31722 NZ_AP018254:c3427095-3426850 [Calothrix sp. NIES-3974]
ATGGAAACTGTAAATATCCATCAAGCCAAGACCAACCTCTCTCGGCTATTGTCCCGTGTAGAACAGGGAGAGGAAATCGT
TATTTCCAACCGAGGTATCCCCATTGCGAAACTTGTTCCCTTTCGGACATCCTTAGATCGACGGTCTAGTTTGGGACAGG
ATCGAGGTCTGTTTACTGTGCCAGATGACTTTAATGCTCCTTTACCAGAAGATATTTTGGTAGCATTTGAAGGTGGCGCA
GAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References