Detailed information of TA system TA031720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 2376800..2377429
• Replicon: chromosome
• Accession: NZ_AP018203
• Organism: Leptolyngbya boryana NIES-2135

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CA740_RS11225
• Protein ID: WP_017286993.1
• Coordinates: 2376800..2377201 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1Z4JFE3
• Locus tag: CA740_RS11230
• Protein ID: WP_017286994.1
• Coordinates: 2377202..2377429 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA740_RS11205	2373187..2374545	-	1359	WP_017286989.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
CA740_RS11210	2374542..2375108	-	567	WP_017286990.1	GNAT family N-acetyltransferase	-
CA740_RS11215	2375115..2376533	-	1419	WP_017286991.1	YdiU family protein	-
CA740_RS11220	2376627..2376773	-	147	Protein_2220	nucleotidyltransferase	-
CA740_RS11225	2376800..2377201	-	402	WP_017286993.1	type II toxin-antitoxin system VapC family toxin	Toxin
CA740_RS11230	2377202..2377429	-	228	WP_017286994.1	virulence factor	Antitoxin
CA740_RS11235	2377442..2377634	-	193	Protein_2223	hypothetical protein	-
CA740_RS11240	2378481..2378858	-	378	WP_017286997.1	nuclear transport factor 2 family protein	-
CA740_RS11245	2379184..2379492	-	309	WP_017286998.1	hypothetical protein	-
CA740_RS11250	2379595..2379855	-	261	WP_017286999.1	hypothetical protein	-
CA740_RS11255	2379955..2380800	-	846	WP_017287000.1	trypsin-like peptidase domain-containing protein	-
CA740_RS11260	2381003..2382235	-	1233	WP_017287001.1	Zn-dependent hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14816.21 Da
• Isoelectric Point: 5.8399

>T31720 WP_017286993.1 NZ_AP018203:c2377201-2376800 [Leptolyngbya boryana NIES-2135]
MQYLLDTNICIYLIKQRPPKVLERFSNLALSDIGISSITVAELEYGVCKSQQREKNRNALMQFLIPLEIVAFDQAAATLY
GAIRSDLESRGLVIGAMDMLIAAHALSLSVTLVSNNVREFSRIANLSLQNWAE

Nucleotide

• Length: 402 bp

>T31720 NZ_AP018203:c2377201-2376800 [Leptolyngbya boryana NIES-2135]
ATGCAATATCTGTTGGACACGAACATCTGCATCTATTTGATTAAGCAAAGACCTCCAAAGGTATTGGAGCGATTTTCAAA
TCTTGCTTTGTCAGATATCGGCATATCCTCTATCACTGTGGCGGAACTAGAATATGGCGTTTGCAAAAGCCAGCAACGAG
AGAAAAACCGTAATGCTTTGATGCAATTTTTAATCCCGCTAGAAATCGTTGCGTTTGATCAAGCGGCTGCGACCCTCTAT
GGCGCAATCAGAAGCGATCTAGAAAGTAGAGGACTGGTTATCGGAGCAATGGACATGCTGATTGCTGCCCACGCATTGAG
CCTTAGCGTTACGTTAGTCAGCAACAATGTGCGAGAGTTTTCACGCATTGCCAATCTATCTCTGCAAAACTGGGCAGAAT
GA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8511.74 Da
• Isoelectric Point: 4.5007

>AT31720 WP_017286994.1 NZ_AP018203:c2377429-2377202 [Leptolyngbya boryana NIES-2135]
MNIAKLSTDGTHQIVILPEDCKMTGTEVYIKKVGSAIVLIAKDHPWQSLFDSLEQFSEDFMTTREQPPLDVREAF

Nucleotide

• Length: 228 bp

>AT31720 NZ_AP018203:c2377429-2377202 [Leptolyngbya boryana NIES-2135]
ATGAATATTGCCAAACTTAGCACCGATGGCACCCATCAAATTGTCATACTCCCCGAAGACTGCAAAATGACGGGTACGGA
GGTCTACATTAAAAAAGTTGGAAGTGCGATCGTTCTAATTGCCAAAGATCATCCTTGGCAATCGCTCTTCGATAGCTTAG
AGCAATTCTCTGAAGACTTCATGACCACGAGAGAGCAGCCCCCTCTCGACGTTCGTGAGGCTTTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Z4JFE3