Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 2061045..2061607 Replicon chromosome
Accession NZ_AP018203
Organism Leptolyngbya boryana NIES-2135

Toxin (Protein)


Gene name vapC Uniprot ID A0A1Z4JEA4
Locus tag CA740_RS09415 Protein ID WP_017286620.1
Coordinates 2061266..2061607 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1Z4JEC0
Locus tag CA740_RS09410 Protein ID WP_017286619.1
Coordinates 2061045..2061269 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA740_RS09395 2057709..2058398 - 690 WP_017286616.1 glycoside hydrolase family protein -
CA740_RS09400 2058464..2060098 - 1635 WP_017286617.1 ABC transporter ATP-binding protein -
CA740_RS09405 2060148..2060834 - 687 WP_017286618.1 SEC59/DGK1/VTE5 family protein -
CA740_RS09410 2061045..2061269 + 225 WP_017286619.1 DUF433 domain-containing protein Antitoxin
CA740_RS09415 2061266..2061607 + 342 WP_017286620.1 DUF5615 family PIN-like protein Toxin
CA740_RS09420 2061652..2062473 - 822 WP_017286621.1 slipin family protein -
CA740_RS09425 2062566..2063492 - 927 WP_017286622.1 branched-chain amino acid ABC transporter permease -
CA740_RS09430 2063489..2064439 - 951 WP_017286623.1 branched-chain amino acid ABC transporter permease -
CA740_RS09435 2064481..2065665 - 1185 WP_017286624.1 ABC transporter substrate-binding protein -
CA740_RS09440 2065730..2066440 - 711 WP_017286625.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(4-79)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12378.18 Da        Isoelectric Point: 4.1314

>T31719 WP_017286620.1 NZ_AP018203:2061266-2061607 [Leptolyngbya boryana NIES-2135]
VTTIWIDAHLSPVIATWITGRFGITAIALRDIGLRDAEDPEIFEAAKAQGVIFMTKDSDFVDLVERLEAPPQIIWLTCGN
TSNARLQEILSSTLPDALELLKSGEKLVEISGE

Download         Length: 342 bp

>T31719 NZ_AP018203:2061266-2061607 [Leptolyngbya boryana NIES-2135]
GTGACAACGATTTGGATCGATGCCCATTTGTCGCCTGTGATCGCAACTTGGATTACAGGCAGATTTGGAATTACCGCGAT
CGCTTTACGGGATATCGGCTTGAGAGATGCCGAAGATCCCGAAATCTTTGAGGCTGCAAAAGCTCAAGGCGTTATATTCA
TGACTAAAGATAGCGATTTCGTGGATCTCGTTGAACGTTTGGAAGCACCGCCACAAATTATTTGGTTAACTTGTGGCAAT
ACATCAAATGCCCGTTTGCAGGAAATTCTAAGCTCGACTTTGCCTGATGCATTAGAGTTATTGAAATCTGGCGAAAAGCT
AGTAGAGATTAGCGGAGAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8186.57 Da        Isoelectric Point: 7.8330

>AT31719 WP_017286619.1 NZ_AP018203:2061045-2061269 [Leptolyngbya boryana NIES-2135]
MSDLLKRITVNPKQCGGRPCIRGMRIRVSDVLDLFAAGLSAEQILEELPDLERDDLRAALAYASRKVNHPVLVA

Download         Length: 225 bp

>AT31719 NZ_AP018203:2061045-2061269 [Leptolyngbya boryana NIES-2135]
ATGTCAGACTTACTTAAACGAATCACCGTGAATCCTAAGCAATGTGGGGGTCGCCCCTGTATTCGTGGCATGAGAATTCG
AGTGTCCGATGTTTTGGATTTATTTGCAGCAGGGTTAAGTGCTGAACAAATTTTGGAAGAACTGCCTGATCTGGAAAGAG
ATGATTTAAGAGCAGCACTTGCCTACGCTTCACGTAAAGTCAACCACCCTGTTTTAGTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z4JEA4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z4JEC0

References