Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 8235003..8235616 Replicon chromosome
Accession NZ_AP018172
Organism Calothrix sp. NIES-2098

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CA733_RS34090 Protein ID WP_096594766.1
Coordinates 8235003..8235389 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CA733_RS34095 Protein ID WP_096594767.1
Coordinates 8235386..8235616 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA733_RS34055 8230337..8231014 - 678 WP_096594761.1 rhomboid family intramembrane serine protease -
CA733_RS34060 8231157..8231870 - 714 WP_096594762.1 rhomboid family intramembrane serine protease -
CA733_RS34065 8232118..8232711 + 594 WP_096594763.1 DUF479 domain-containing protein -
CA733_RS34070 8232788..8233483 + 696 WP_096594764.1 Uma2 family endonuclease -
CA733_RS34075 8233682..8234302 + 621 WP_096594765.1 hypothetical protein -
CA733_RS34080 8234472..8234711 - 240 Protein_6725 hypothetical protein -
CA733_RS34085 8234748..8234957 - 210 Protein_6726 hypothetical protein -
CA733_RS34090 8235003..8235389 - 387 WP_096594766.1 type II toxin-antitoxin system VapC family toxin Toxin
CA733_RS34095 8235386..8235616 - 231 WP_096594767.1 DUF2281 domain-containing protein Antitoxin
CA733_RS34100 8235744..8237741 - 1998 WP_096594768.1 excinuclease ABC subunit UvrB -
CA733_RS34105 8237991..8238461 + 471 WP_096594769.1 hypothetical protein -
CA733_RS34110 8238882..8239064 + 183 WP_096594770.1 CsbD family protein -
CA733_RS34115 8239305..8239745 + 441 WP_096594771.1 hypothetical protein -
CA733_RS34120 8239820..8240341 + 522 WP_096594772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-127)

Antitoxin

Domain of unknown function DUF2281

(6-74)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14578.77 Da        Isoelectric Point: 5.5217

>T31716 WP_096594766.1 NZ_AP018172:c8235389-8235003 [Calothrix sp. NIES-2098]
MSAFLLDTHAFIWLTENDSSLPYNLRMTINNADFVYLSIASLWEIAIKLNLGKLSLQRSYETIGSAIDASDILLLPISFG
DTVQVRNLPLHHGDPFDRMLIAQAINHSLIIISRDKKFDAYSVQRLWE

Download         Length: 387 bp

>T31716 NZ_AP018172:c8235389-8235003 [Calothrix sp. NIES-2098]
ATGAGTGCTTTTCTGTTAGATACTCATGCCTTTATCTGGCTCACTGAAAATGACTCTAGTCTTCCATATAATCTGAGAAT
GACAATCAATAATGCAGATTTCGTTTATCTCAGCATCGCTAGTCTTTGGGAAATTGCCATCAAGTTGAACCTTGGTAAAT
TATCGTTGCAACGGAGTTATGAAACAATAGGTTCTGCAATTGACGCTTCAGATATCCTCCTACTTCCGATATCTTTTGGT
GATACGGTTCAAGTTCGCAATCTCCCGCTACATCATGGCGATCCATTTGACCGGATGTTGATTGCACAGGCTATTAATCA
CTCTTTAATAATTATTAGCAGGGATAAAAAATTTGATGCTTATTCTGTTCAGAGATTGTGGGAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8848.02 Da        Isoelectric Point: 4.1942

>AT31716 WP_096594767.1 NZ_AP018172:c8235616-8235386 [Calothrix sp. NIES-2098]
MAIDAEILQTLEQMPESLKQEILHYAKYLLENYSKSVSQESSVQQKHRSGILKGTFVLPLPDDFDEPLEVFQEYME

Download         Length: 231 bp

>AT31716 NZ_AP018172:c8235616-8235386 [Calothrix sp. NIES-2098]
ATGGCTATTGATGCAGAAATTTTACAAACACTAGAGCAAATGCCAGAGTCACTTAAACAAGAAATCTTGCATTATGCCAA
ATATCTACTTGAGAATTATTCAAAAAGTGTTTCTCAGGAAAGCTCAGTACAACAAAAACATCGTTCTGGAATTTTAAAAG
GAACTTTTGTTTTACCTTTACCTGATGACTTTGATGAACCTCTTGAAGTCTTTCAGGAATATATGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References