Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 7253654..7254231 Replicon chromosome
Accession NZ_AP018172
Organism Calothrix sp. NIES-2098

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CA733_RS30010 Protein ID WP_096594021.1
Coordinates 7253654..7253983 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CA733_RS30015 Protein ID WP_096594023.1
Coordinates 7253971..7254231 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA733_RS29985 7248761..7249477 + 717 WP_096594013.1 hypothetical protein -
CA733_RS29990 7249547..7249993 + 447 WP_096594015.1 DUF2127 domain-containing protein -
CA733_RS29995 7250017..7252299 - 2283 WP_096594017.1 FUSC family protein -
CA733_RS30000 7252839..7253051 + 213 WP_096595440.1 transferase hexapeptide repeat containing protein -
CA733_RS30005 7253054..7253482 + 429 WP_096594019.1 type II toxin-antitoxin system VapC family toxin -
CA733_RS30010 7253654..7253983 - 330 WP_096594021.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CA733_RS30015 7253971..7254231 - 261 WP_096594023.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CA733_RS30020 7254513..7255535 + 1023 WP_096594025.1 saccharopine dehydrogenase-like oxidoreductase -
CA733_RS30025 7255650..7256594 - 945 WP_096594027.1 GDP-L-fucose synthase -
CA733_RS30030 7256622..7257701 - 1080 WP_096594029.1 GDP-mannose 4,6-dehydratase -
CA733_RS30035 7258308..7259066 - 759 WP_096594031.1 sugar transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-106)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12401.53 Da        Isoelectric Point: 8.5307

>T31714 WP_096594021.1 NZ_AP018172:c7253983-7253654 [Calothrix sp. NIES-2098]
MAMVIKRFDVFLVNLDPTIGTEIKKTRPCVVISPDEMNRHIATVIVAPMTTKGQPYPTRVACRFQDKDRQIVLDQIRTVD
KTRLINRLGTISSDEQRAVIDILAEMFAD

Download         Length: 330 bp

>T31714 NZ_AP018172:c7253983-7253654 [Calothrix sp. NIES-2098]
ATGGCAATGGTAATCAAGCGTTTTGATGTGTTCCTTGTTAATCTCGATCCCACTATTGGCACTGAAATTAAAAAAACACG
TCCCTGTGTAGTGATTTCACCAGACGAGATGAACCGTCATATTGCTACGGTCATTGTTGCACCTATGACTACAAAAGGTC
AGCCATATCCCACAAGGGTAGCTTGTCGCTTTCAAGACAAAGATAGGCAGATTGTTCTAGATCAAATTCGCACAGTAGAT
AAAACTCGATTAATTAATCGTCTCGGTACGATTAGTTCTGATGAGCAAAGAGCAGTTATCGATATCTTAGCTGAGATGTT
TGCCGATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9795.09 Da        Isoelectric Point: 4.8182

>AT31714 WP_096594023.1 NZ_AP018172:c7254231-7253971 [Calothrix sp. NIES-2098]
MGAAIRTRIVKIGNSQGIRIPKPLLEQSGISTEVEIEVHGDRLILRPASKLRVGWDEAFATMAERHDDVLLDDVNTTDWD
RAEWQW

Download         Length: 261 bp

>AT31714 NZ_AP018172:c7254231-7253971 [Calothrix sp. NIES-2098]
ATGGGCGCAGCTATTAGAACCAGAATAGTGAAAATCGGTAATTCTCAAGGTATTCGTATTCCCAAACCTCTGTTAGAGCA
AAGTGGTATTAGTACAGAGGTGGAAATTGAGGTGCATGGCGATCGCTTAATTCTTCGTCCAGCATCAAAATTACGGGTTG
GGTGGGACGAAGCTTTTGCCACAATGGCAGAACGGCACGATGATGTTCTCTTAGATGACGTTAATACAACAGACTGGGAT
CGGGCTGAATGGCAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References