Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 4426647..4427313 Replicon chromosome
Accession NZ_AP018164
Organism Mycobacterium shigaense strain JCM 32072

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MSG_RS20610 Protein ID WP_096442529.1
Coordinates 4426647..4427120 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag MSG_RS20615 Protein ID WP_096442531.1
Coordinates 4427125..4427313 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSG_RS20590 4422932..4424158 + 1227 WP_096442521.1 acetyl-CoA acetyltransferase -
MSG_RS20595 4424161..4425675 + 1515 WP_096442523.1 carotenoid oxygenase family protein -
MSG_RS20600 4425672..4426151 + 480 WP_096442525.1 VOC family protein -
MSG_RS20605 4426155..4426589 - 435 WP_096442527.1 hypothetical protein -
MSG_RS20610 4426647..4427120 - 474 WP_096442529.1 SRPBCC family protein Toxin
MSG_RS20615 4427125..4427313 - 189 WP_096442531.1 antitoxin Antitoxin
MSG_RS20620 4427463..4429856 - 2394 WP_096442533.1 cation-translocating P-type ATPase -
MSG_RS20625 4429853..4431436 - 1584 WP_096442535.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-141)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17165.94 Da        Isoelectric Point: 10.0646

>T31712 WP_096442529.1 NZ_AP018164:c4427120-4426647 [Mycobacterium shigaense]
MAKLSGSIDVPLPPHQAWQHASDLSRYKDWLSIHRVWRSKLPDVLEKGTVIESIVEVKGMLNRIKWTIVHYKPPEAMTLN
GDGVGGVKVKLMAKVKQKEDGSVVSFDVHLGGPALFGPIGMIVAAALKGDINQSLEQFVTVFTSPDPGMNGDRGARR

Download         Length: 474 bp

>T31712 NZ_AP018164:c4427120-4426647 [Mycobacterium shigaense]
ATGGCCAAACTCTCCGGATCCATCGACGTACCGCTGCCGCCCCACCAGGCGTGGCAGCATGCCTCTGACCTGTCCCGCTA
CAAGGACTGGCTGAGCATCCACCGCGTGTGGCGCAGCAAATTGCCCGACGTGCTGGAGAAGGGCACGGTGATCGAATCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAGTGGACGATCGTGCACTACAAGCCGCCGGAGGCGATGACGCTCAAC
GGCGACGGTGTGGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTCAAGCAGAAGGAAGACGGCTCTGTGGTCAGCTTCGA
CGTGCACCTCGGCGGCCCGGCGCTGTTCGGGCCGATCGGCATGATCGTCGCGGCCGCGCTGAAGGGCGACATCAATCAGT
CACTGGAGCAGTTCGTGACGGTGTTCACCTCTCCCGATCCCGGCATGAATGGCGACCGCGGCGCGCGGCGCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6671.33 Da        Isoelectric Point: 4.7027

>AT31712 WP_096442531.1 NZ_AP018164:c4427313-4427125 [Mycobacterium shigaense]
MGLLDKAKDLLAQNADKVGTAIDKAGEFVDDKTQGKYSDTIHQVQEQAKKAAEAAAKDDDHN

Download         Length: 189 bp

>AT31712 NZ_AP018164:c4427313-4427125 [Mycobacterium shigaense]
ATGGGATTGCTGGACAAAGCGAAGGACTTGCTGGCGCAGAATGCCGACAAGGTGGGGACGGCGATCGACAAGGCGGGCGA
GTTCGTCGACGACAAGACGCAGGGCAAGTACTCCGACACCATTCACCAGGTGCAGGAACAAGCCAAGAAAGCCGCCGAGG
CGGCGGCCAAGGACGACGACCACAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References