Detailed information of TA system TA031709

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1852523..1853166
• Replicon: chromosome
• Accession: NZ_AP018150
• Organism: Mycoavidus cysteinexigens strain B1EB

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MCB1EB_RS07935
• Protein ID: WP_045361497.1
• Coordinates: 1852523..1852924 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2Z6EWA4
• Locus tag: MCB1EB_RS07940
• Protein ID: WP_026921980.1
• Coordinates: 1852924..1853166 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MCB1EB_RS07895	1847554..1847754	+	201	WP_045361507.1	hypothetical protein	-
MCB1EB_RS07900	1847817..1848653	+	837	WP_126353977.1	hypothetical protein	-
MCB1EB_RS07905	1848661..1849314	+	654	WP_126353978.1	hypothetical protein	-
MCB1EB_RS07910	1849337..1849756	+	420	WP_126353979.1	RusA family crossover junction endodeoxyribonuclease	-
MCB1EB_RS07915	1849756..1850157	+	402	WP_126353923.1	hypothetical protein	-
MCB1EB_RS07920	1850154..1850393	+	240	WP_126353924.1	hypothetical protein	-
MCB1EB_RS07925	1850560..1851030	+	471	WP_045361503.1	hypothetical protein	-
MCB1EB_RS07930	1850981..1852516	+	1536	WP_045361500.1	phage terminase large subunit	-
MCB1EB_RS07935	1852523..1852924	-	402	WP_045361497.1	type II toxin-antitoxin system VapC family toxin	Toxin
MCB1EB_RS07940	1852924..1853166	-	243	WP_026921980.1	twitching motility protein PilT	Antitoxin
MCB1EB_RS07945	1853359..1854765	+	1407	WP_052393549.1	DUF1073 domain-containing protein	-
MCB1EB_RS07950	1854701..1855534	+	834	WP_045361487.1	minor capsid protein	-
MCB1EB_RS07955	1855531..1856631	+	1101	WP_052393547.1	DUF2213 domain-containing protein	-
MCB1EB_RS07960	1856657..1857187	+	531	WP_126353980.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1792743..1898496	105753
	-	inside	Prophage	-	-	1738810..1898496	159686

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14447.58 Da
• Isoelectric Point: 4.8615

>T31709 WP_045361497.1 NZ_AP018150:c1852924-1852523 [Mycoavidus cysteinexigens]
MALYLLDTNILSDILKNPQGLAAQKLTEHPQESLCTSIIVAAEMRYGAAKKNAEALTERVNQLLDVIKILSFSPDADHCY
GQVRAELERKGQTIGANDLLIAAHALSVDAILVTANVNEFSRVSGLAMENWLA

Nucleotide

• Length: 402 bp

>T31709 NZ_AP018150:c1852924-1852523 [Mycoavidus cysteinexigens]
ATGGCGCTGTATCTGCTTGATACCAATATCCTTTCAGATATTCTGAAAAACCCACAAGGACTCGCTGCGCAAAAACTCAC
CGAGCATCCGCAAGAATCCCTATGCACCAGTATTATCGTTGCAGCGGAGATGCGCTACGGTGCAGCAAAGAAAAATGCAG
AAGCATTAACCGAGCGAGTAAACCAATTACTTGACGTGATTAAAATACTTTCGTTCTCACCCGACGCGGACCACTGCTAT
GGGCAAGTTCGCGCCGAACTTGAACGAAAAGGGCAAACCATAGGTGCGAATGATTTACTGATTGCTGCTCATGCTTTATC
GGTAGATGCGATACTTGTTACAGCGAACGTCAATGAATTTAGCCGAGTCTCCGGATTGGCGATGGAAAACTGGTTAGCCT
AG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9118.49 Da
• Isoelectric Point: 4.7661

>AT31709 WP_026921980.1 NZ_AP018150:c1853166-1852924 [Mycoavidus cysteinexigens]
MVNTYPERHVKLFRNGKNQAVRIPVEFELNGSDAIMRRENNRLIIELAPPRSLSALLASWTPLQEGLPEIVDLPPEDVEL

Nucleotide

• Length: 243 bp

>AT31709 NZ_AP018150:c1853166-1852924 [Mycoavidus cysteinexigens]
ATGGTGAATACTTATCCAGAACGCCACGTTAAACTATTCAGGAATGGAAAAAATCAAGCTGTGCGCATCCCTGTTGAATT
TGAGTTAAACGGGTCTGATGCCATCATGCGTCGTGAAAATAATCGACTGATTATTGAGCTTGCGCCACCGCGCTCTTTAT
CTGCGCTGTTAGCAAGCTGGACTCCGCTCCAAGAAGGGCTACCGGAGATCGTAGATCTTCCCCCCGAAGACGTGGAGCTT
TGA

Structures

Antitoxin

• AlphaFold DB: A0A2Z6EWA4