Detailed information of TA system TA031699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 973864..974519
• Replicon: chromosome
• Accession: NZ_AP018112
• Organism: Burkholderia stabilis strain FERMP-21014

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0G3X0G1
• Locus tag: BSFP_RS21480
• Protein ID: WP_047902814.1
• Coordinates: 974100..974519 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BSFP_RS21475
• Protein ID: WP_096473859.1
• Coordinates: 973864..974103 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSFP_RS21460	969870..970553	-	684	WP_096473856.1	Fe2+-dependent dioxygenase	-
BSFP_RS21465	970550..971305	-	756	WP_096473857.1	sel1 repeat family protein	-
BSFP_RS21470	971309..973552	-	2244	WP_096473858.1	TonB-dependent siderophore receptor	-
BSFP_RS21475	973864..974103	+	240	WP_096473859.1	Arc family DNA-binding protein	Antitoxin
BSFP_RS21480	974100..974519	+	420	WP_047902814.1	type II toxin-antitoxin system VapC family toxin	Toxin
BSFP_RS21485	974651..975946	-	1296	WP_096473860.1	aspartate carbamoyltransferase	-
BSFP_RS21490	976180..976314	+	135	WP_009688930.1	entericidin A/B family lipoprotein	-
BSFP_RS21495	976417..976989	-	573	WP_096473861.1	permease	-
BSFP_RS21500	977176..978144	-	969	WP_096475581.1	DMT family transporter	-
BSFP_RS21510	978581..979375	-	795	WP_096473862.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15230.59 Da
• Isoelectric Point: 7.0193

>T31699 WP_047902814.1 NZ_AP018112:974100-974519 [Burkholderia stabilis]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAVLPEGRRREWLHRSIEQRVVPLFRGRILPFDD
AASKAYASVRARARVAGNAIAPVDGFIAATADANGLIVATRDVAPFEAVGLRVIDPWAR

Nucleotide

• Length: 420 bp

>T31699 NZ_AP018112:974100-974519 [Burkholderia stabilis]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTGCGACGCGAGCCGAGCGCAGCGGTGATCGAGTGGCTCGATGC
CCAGAACGTCGAAACGCTGTTTCTTGCCGCGATCAGTCTCGCGGAGATGCGATTCGGCGTGGCTGTATTGCCGGAAGGGC
GAAGGCGCGAGTGGCTGCATCGAAGCATCGAACAGCGTGTCGTGCCATTGTTTCGAGGCCGGATCCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATGCGAGCGTTCGGGCGCGGGCCCGTGTCGCAGGCAACGCGATCGCGCCTGTCGATGGTTTTAT
CGCCGCCACGGCAGACGCGAACGGCCTGATCGTGGCCACGCGGGACGTCGCGCCGTTCGAGGCGGTGGGGCTTCGCGTGA
TCGATCCGTGGGCGCGCTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8770.00 Da
• Isoelectric Point: 6.4653

>AT31699 WP_096473859.1 NZ_AP018112:973864-974103 [Burkholderia stabilis]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVYFDIQRDKTSTDPMSFE

Nucleotide

• Length: 240 bp

>AT31699 NZ_AP018112:973864-974103 [Burkholderia stabilis]
ATGCCGGTGATCACCGTTCGAAATTTGCCCGATGAAGTGCATCGCGCACTTCGGATTCGCGCGGCCCAGCACGGGCGCAG
CACCGAAGCCGAGGTACGTGACATTCTCGAGCAGGCCGTCCTGCCAGGTGGGCGGCTCAAGCTGGGAACGTTGCTGGCGG
AAATCGGGCGGGAGGCTGGGGGAGTCTATTTCGACATCCAGCGCGACAAGACGTCAACCGATCCGATGAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0G3X0G1