Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 899467..899990 Replicon chromosome
Accession NZ_AP018112
Organism Burkholderia stabilis strain FERMP-21014

Toxin (Protein)


Gene name relE Uniprot ID Q399A4
Locus tag BSFP_RS21095 Protein ID WP_011354451.1
Coordinates 899467..899733 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1D7ZL89
Locus tag BSFP_RS21100 Protein ID WP_069748763.1
Coordinates 899730..899990 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSFP_RS21070 895100..896014 + 915 WP_096473797.1 LysR family transcriptional regulator -
BSFP_RS21075 896072..896671 + 600 WP_096473798.1 GNAT family N-acetyltransferase -
BSFP_RS21080 896807..897376 - 570 WP_096473799.1 DUF4142 domain-containing protein -
BSFP_RS21085 897767..898390 - 624 WP_096473800.1 HAD hydrolase-like protein -
BSFP_RS21090 898408..899139 - 732 WP_096475573.1 substrate-binding domain-containing protein -
BSFP_RS21095 899467..899733 - 267 WP_011354451.1 Txe/YoeB family addiction module toxin Toxin
BSFP_RS21100 899730..899990 - 261 WP_069748763.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BSFP_RS21105 900217..900660 + 444 WP_048245578.1 GNAT family N-acetyltransferase -
BSFP_RS21110 900718..900936 + 219 WP_006480837.1 DUF1653 domain-containing protein -
BSFP_RS21115 900960..901418 - 459 WP_096473801.1 ATP synthase F1 subunit epsilon -
BSFP_RS21120 901429..902298 - 870 WP_096473802.1 ATP synthase F1 subunit gamma -
BSFP_RS21125 902444..903403 + 960 WP_096475574.1 phosphate acetyltransferase -
BSFP_RS21130 903414..904622 + 1209 WP_096473803.1 acetate/propionate family kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10526.86 Da        Isoelectric Point: 7.9861

>T31698 WP_011354451.1 NZ_AP018112:c899733-899467 [Burkholderia stabilis]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYE

Download         Length: 267 bp

>T31698 NZ_AP018112:c899733-899467 [Burkholderia stabilis]
ATGAGCGTACGCCGCGTGCTCTTTACTTCCGACGCGTGGGACGACTATGTCTATTGGCAAGGGCAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAGCGGACGCCGTTCGAAGGCATCGGCAAGCCCGAACCGTTGAAGGCCA
ACCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAGATCAGCATC
GTGTCCTGCCGCTATCACTACGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9764.05 Da        Isoelectric Point: 6.2225

>AT31698 WP_069748763.1 NZ_AP018112:c899990-899730 [Burkholderia stabilis]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKERK
LAEDDE

Download         Length: 261 bp

>AT31698 NZ_AP018112:c899990-899730 [Burkholderia stabilis]
ATGCGCACGATTCATTTTTCGGATGCACGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATCACGCGCCGCGATGCCCCGAACGCCGTCATCATGTCGCAGGACTACTACGACAGTCTGATGGAGACGGTTCACT
TGCTGCGCTCGCCGGCTAACGTCGCCCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACGCAAG
CTCGCCGAGGATGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J9NJ39

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7ZL89

References