Detailed information of TA system TA031696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 162665..163184
• Replicon: chromosome
• Accession: NZ_AP018112
• Organism: Burkholderia stabilis strain FERMP-21014

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BSFP_RS17785
• Protein ID: WP_096473290.1
• Coordinates: 162903..163184 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0G3WYJ8
• Locus tag: BSFP_RS17780
• Protein ID: WP_047902230.1
• Coordinates: 162665..162913 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSFP_RS17770	160162..161355	+	1194	WP_096473288.1	2-methylaconitate cis-trans isomerase PrpF	-
BSFP_RS17775	161494..162546	+	1053	WP_096473289.1	CoA transferase	-
BSFP_RS17780	162665..162913	+	249	WP_047902230.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BSFP_RS17785	162903..163184	+	282	WP_096473290.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSFP_RS17790	163241..163684	-	444	WP_047902232.1	PaaI family thioesterase	-
BSFP_RS17795	163976..165604	+	1629	WP_096473291.1	Tar ligand binding domain-containing protein	-
BSFP_RS17800	165577..166686	-	1110	WP_096473292.1	AGE family epimerase/isomerase	-
BSFP_RS17805	166798..167496	+	699	WP_096473293.1	MgtC/SapB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-78)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10931.81 Da
• Isoelectric Point: 10.8400

>T31696 WP_096473290.1 NZ_AP018112:162903-163184 [Burkholderia stabilis]
MTFELAFLEAALKEWKKLDRTVRDQFKARLAERLENPRLPSAKLHGHPDRYKIKLRSVGYRLVYEVRDAEVVVLVVAVGR
RERDAVHFAAMKR

Nucleotide

• Length: 282 bp

>T31696 NZ_AP018112:162903-163184 [Burkholderia stabilis]
ATGACCTTTGAGCTCGCCTTTCTCGAAGCTGCGTTGAAGGAGTGGAAGAAGCTCGATCGCACCGTTCGCGATCAGTTCAA
GGCCAGGCTCGCCGAACGGCTCGAGAATCCTCGCCTTCCATCGGCGAAGCTGCACGGTCATCCGGACCGCTACAAGATCA
AGCTGCGCAGTGTCGGCTATCGCCTCGTGTACGAAGTGCGCGATGCGGAAGTCGTCGTACTGGTTGTCGCGGTGGGGCGT
CGCGAGCGCGATGCGGTCCATTTCGCCGCAATGAAACGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8935.26 Da
• Isoelectric Point: 5.0636

>AT31696 WP_047902230.1 NZ_AP018112:162665-162913 [Burkholderia stabilis]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRAKEKAVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT31696 NZ_AP018112:162665-162913 [Burkholderia stabilis]
ATGCCCCACACCATTCTGGCCAGCGTGACGGCGAGCGTCTCGGAGCTGAAGCGGAACCCGATGGGAACCGTGGCGGCGGG
CGAGGGCTTTCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTATTGCATCCCGGCGAAGACATGGGAGGCGATGG
TCGAACGTCTCGAAGATATCGAAGACAACGCGCTGGCCGACTCGCGCGCCAAGGAGAAAGCCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0G3WYJ8