Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1385145..1385784 Replicon chromosome
Accession NZ_AP018052
Organism Thiohalobacter thiocyanaticus strain FOKN1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CFK21_RS06445 Protein ID WP_096365870.1
Coordinates 1385368..1385784 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CFK21_RS06440 Protein ID WP_096365868.1
Coordinates 1385145..1385381 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFK21_RS06425 1380459..1381697 + 1239 WP_096365862.1 dissimilatory-type sulfite reductase subunit alpha -
CFK21_RS06430 1381751..1382824 + 1074 WP_096365864.1 dissimilatory-type sulfite reductase subunit beta -
CFK21_RS06435 1383115..1384296 + 1182 WP_096365866.1 cyclopropane fatty acyl phospholipid synthase -
CFK21_RS06440 1385145..1385381 + 237 WP_096365868.1 DNA-binding protein Antitoxin
CFK21_RS06445 1385368..1385784 + 417 WP_096365870.1 type II toxin-antitoxin system VapC family toxin Toxin
CFK21_RS06450 1385858..1386796 - 939 WP_096365872.1 MBL fold metallo-hydrolase -
CFK21_RS06455 1386882..1388264 - 1383 WP_096365874.1 chromate efflux transporter -
CFK21_RS06460 1388309..1389268 - 960 WP_096365876.1 chromate resistance protein -
CFK21_RS15160 1389596..1389970 + 375 WP_157745423.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1380459..1480601 100142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15799.23 Da        Isoelectric Point: 6.9804

>T31689 WP_096365870.1 NZ_AP018052:1385368-1385784 [Thiohalobacter thiocyanaticus]
MFLIDTNVISELRKRQNANPGVRAFFEQSVADEAPLFISVVTVGELRRGVELIRHRGDAPQAHLLERWLTSLMAEYQECI
LDITPDIAQLWGRLRVPHPEHALDKFIAATALIYELKVVTRNHKDFRATGLEVVNPFR

Download         Length: 417 bp

>T31689 NZ_AP018052:1385368-1385784 [Thiohalobacter thiocyanaticus]
ATGTTTTTGATTGATACCAACGTCATCAGTGAGCTGCGCAAGCGGCAGAATGCCAACCCCGGCGTGAGGGCCTTCTTCGA
ACAGTCGGTTGCCGATGAGGCGCCCCTGTTTATCTCGGTGGTCACCGTTGGCGAACTGCGGCGGGGCGTGGAACTGATCC
GTCATCGTGGTGATGCGCCTCAGGCACACCTGCTGGAACGATGGCTGACGTCTCTGATGGCCGAATATCAGGAATGTATC
CTCGATATTACACCGGATATTGCCCAGCTCTGGGGGCGCTTGCGAGTCCCCCATCCTGAGCATGCACTGGATAAATTCAT
TGCCGCCACCGCACTCATCTACGAGCTTAAGGTGGTCACACGCAATCACAAGGATTTTCGTGCTACCGGCCTGGAAGTGG
TGAATCCCTTCCGTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8703.82 Da        Isoelectric Point: 5.1311

>AT31689 WP_096365868.1 NZ_AP018052:1385145-1385381 [Thiohalobacter thiocyanaticus]
MANLVVRNLDPRIVAALKQRAARHGRSAEAEHRTLLEAVLLRPRGRSFAEALAAIPEVGEDEDFERAEDTDCLPHVFD

Download         Length: 237 bp

>AT31689 NZ_AP018052:1385145-1385381 [Thiohalobacter thiocyanaticus]
ATGGCCAATCTGGTGGTCCGGAACCTCGATCCGCGGATCGTAGCTGCTCTGAAGCAGCGTGCCGCACGGCACGGGCGCAG
CGCTGAAGCCGAGCATCGCACTCTGTTGGAGGCGGTGTTACTGCGACCCCGTGGCCGAAGCTTCGCGGAAGCGCTGGCCG
CCATTCCCGAAGTCGGGGAGGATGAAGACTTCGAGCGGGCCGAGGACACAGATTGTCTGCCGCATGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References