31681

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3119305..3119909 Replicon chromosome
Accession NZ_AP018036
Organism Mycobacterium tuberculosis strain HN-506

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag CPZ04_RS15375 Protein ID WP_003414492.1
Coordinates 3119305..3119697 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag CPZ04_RS15380 Protein ID WP_003414495.1
Coordinates 3119694..3119909 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ04_RS15345 3114455..3115243 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
CPZ04_RS15350 3115577..3116122 - 546 WP_014584866.1 DUF1802 family protein -
CPZ04_RS15355 3116394..3117278 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CPZ04_RS15360 3117281..3118168 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
CPZ04_RS15365 3118473..3119018 - 546 WP_096362314.1 DUF1802 family protein -
CPZ04_RS15370 3119015..3119284 - 270 WP_003414489.1 DUF2277 family protein -
CPZ04_RS15375 3119305..3119697 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
CPZ04_RS15380 3119694..3119909 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CPZ04_RS15385 3119956..3120705 + 750 WP_003902358.1 enoyl-CoA hydratase -
CPZ04_RS15390 3120784..3121866 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
CPZ04_RS15395 3121859..3123169 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
CPZ04_RS15400 3123172..3123999 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
CPZ04_RS15405 3123996..3124907 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T31681 WP_003414492.1 NZ_AP018036:c3119697-3119305 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T31681 NZ_AP018036:c3119697-3119305 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT31681 WP_003414495.1 NZ_AP018036:c3119909-3119694 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT31681 NZ_AP018036:c3119909-3119694 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References