Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3099107..3099677 | Replicon | chromosome |
Accession | NZ_AP018036 | ||
Organism | Mycobacterium tuberculosis strain HN-506 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | CPZ04_RS15250 | Protein ID | WP_003414166.1 |
Coordinates | 3099107..3099463 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | CPZ04_RS15255 | Protein ID | WP_003901465.1 |
Coordinates | 3099447..3099677 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CPZ04_RS15230 | 3094559..3096247 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
CPZ04_RS15235 | 3096251..3096577 | - | 327 | WP_003414157.1 | hypothetical protein | - |
CPZ04_RS15240 | 3096750..3097337 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
CPZ04_RS15245 | 3097356..3099005 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
CPZ04_RS15250 | 3099107..3099463 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
CPZ04_RS15255 | 3099447..3099677 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
CPZ04_RS15260 | 3099720..3100763 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
CPZ04_RS15265 | 3100954..3101229 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
CPZ04_RS21835 | 3101405..3101659 | - | 255 | WP_003917684.1 | hypothetical protein | - |
CPZ04_RS15275 | 3101807..3102211 | + | 405 | WP_003414181.1 | hypothetical protein | - |
CPZ04_RS15280 | 3102208..3102399 | + | 192 | WP_003414184.1 | hypothetical protein | - |
CPZ04_RS15285 | 3102463..3103752 | + | 1290 | Protein_2890 | transposase family protein | - |
CPZ04_RS15290 | 3103986..3104243 | + | 258 | WP_003899489.1 | hypothetical protein | - |
CPZ04_RS15295 | 3104348..3104659 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T31679 WP_003414166.1 NZ_AP018036:c3099463-3099107 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T31679 NZ_AP018036:c3099463-3099107 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT31679 WP_003901465.1 NZ_AP018036:c3099677-3099447 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT31679 NZ_AP018036:c3099677-3099447 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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