Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2189757..2190301 | Replicon | chromosome |
| Accession | NZ_AP018036 | ||
| Organism | Mycobacterium tuberculosis strain HN-506 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | CPZ04_RS10535 | Protein ID | WP_003409896.1 |
| Coordinates | 2189757..2190053 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | CPZ04_RS10540 | Protein ID | WP_003409899.1 |
| Coordinates | 2190050..2190301 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPZ04_RS10480 | 2184790..2185140 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| CPZ04_RS10485 | 2185151..2186053 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| CPZ04_RS10490 | 2186074..2186265 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| CPZ04_RS10495 | 2186266..2186562 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| CPZ04_RS10500 | 2186802..2187017 | + | 216 | WP_003409878.1 | antitoxin | - |
| CPZ04_RS10505 | 2187014..2187325 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| CPZ04_RS21795 | 2187299..2187820 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| CPZ04_RS10515 | 2187795..2188172 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| CPZ04_RS10520 | 2188214..2188663 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| CPZ04_RS10525 | 2188660..2189205 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| CPZ04_RS10530 | 2189094..2189708 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| CPZ04_RS10535 | 2189757..2190053 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CPZ04_RS10540 | 2190050..2190301 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| CPZ04_RS10545 | 2190288..2190782 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| CPZ04_RS10550 | 2190942..2191349 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| CPZ04_RS10555 | 2191353..2191625 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| CPZ04_RS10560 | 2191658..2192878 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| CPZ04_RS10575 | 2193777..2194574 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T31661 WP_003409896.1 NZ_AP018036:c2190053-2189757 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T31661 NZ_AP018036:c2190053-2189757 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT31661 WP_003409899.1 NZ_AP018036:c2190301-2190050 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT31661 NZ_AP018036:c2190301-2190050 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |