31612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2870066..2870775 Replicon chromosome
Accession NZ_AP018035
Organism Mycobacterium tuberculosis strain HN-321

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag CPZ12_RS13930 Protein ID WP_003413164.1
Coordinates 2870066..2870479 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag CPZ12_RS13935 Protein ID WP_003413167.1
Coordinates 2870518..2870775 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ12_RS13895 2865120..2866325 - 1206 WP_003413027.1 chorismate synthase -
CPZ12_RS13900 2866433..2866747 + 315 WP_009937839.1 hypothetical protein -
CPZ12_RS13905 2867043..2868254 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
CPZ12_RS13915 2868381..2869040 + 660 WP_003902296.1 hypothetical protein -
CPZ12_RS13920 2869037..2869699 + 663 WP_003905878.1 hypothetical protein -
CPZ12_RS13925 2869696..2869973 + 278 Protein_2631 type II toxin-antitoxin system VapB family antitoxin -
CPZ12_RS13930 2870066..2870479 + 414 WP_003413164.1 PIN domain nuclease Toxin
CPZ12_RS13935 2870518..2870775 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
CPZ12_RS13940 2870772..2871149 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
CPZ12_RS13945 2871165..2871539 - 375 WP_003413177.1 hypothetical protein -
CPZ12_RS13950 2871639..2872034 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
CPZ12_RS13955 2872031..2872276 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
CPZ12_RS13965 2872687..2873106 - 420 WP_003413190.1 A24 family peptidase -
CPZ12_RS13970 2873118..2873927 - 810 WP_003413193.1 shikimate dehydrogenase -
CPZ12_RS13975 2873924..2875177 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
CPZ12_RS13980 2875170..2875682 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T31612 WP_003413164.1 NZ_AP018035:2870066-2870479 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T31612 NZ_AP018035:2870066-2870479 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT31612 WP_003413167.1 NZ_AP018035:2870518-2870775 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT31612 NZ_AP018035:2870518-2870775 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References