Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2195638..2196182 | Replicon | chromosome |
| Accession | NZ_AP018035 | ||
| Organism | Mycobacterium tuberculosis strain HN-321 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | CPZ12_RS10560 | Protein ID | WP_003409896.1 |
| Coordinates | 2195638..2195934 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | CPZ12_RS10565 | Protein ID | WP_003409899.1 |
| Coordinates | 2195931..2196182 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPZ12_RS10505 | 2190671..2191021 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| CPZ12_RS10510 | 2191032..2191934 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| CPZ12_RS10515 | 2191955..2192146 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| CPZ12_RS10520 | 2192147..2192443 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| CPZ12_RS10525 | 2192683..2192898 | + | 216 | WP_003409878.1 | antitoxin | - |
| CPZ12_RS10530 | 2192895..2193206 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| CPZ12_RS21835 | 2193180..2193701 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| CPZ12_RS10540 | 2193676..2194053 | + | 378 | WP_162470919.1 | type II toxin-antitoxin system toxin HigB | - |
| CPZ12_RS10545 | 2194095..2194544 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| CPZ12_RS10550 | 2194541..2195086 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| CPZ12_RS10555 | 2194975..2195589 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| CPZ12_RS10560 | 2195638..2195934 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CPZ12_RS10565 | 2195931..2196182 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| CPZ12_RS10570 | 2196169..2196663 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| CPZ12_RS10575 | 2196823..2197230 | - | 408 | WP_024754015.1 | type II toxin-antitoxin system VapC family toxin | - |
| CPZ12_RS10580 | 2197234..2197506 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| CPZ12_RS10585 | 2197539..2198759 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| CPZ12_RS10600 | 2199658..2200455 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T31601 WP_003409896.1 NZ_AP018035:c2195934-2195638 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T31601 NZ_AP018035:c2195934-2195638 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT31601 WP_003409899.1 NZ_AP018035:c2196182-2195931 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT31601 NZ_AP018035:c2196182-2195931 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |