31590

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1243399..1243967 Replicon chromosome
Accession NZ_AP018035
Organism Mycobacterium tuberculosis strain HN-321

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag CPZ12_RS06095 Protein ID WP_003405865.1
Coordinates 1243593..1243967 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag CPZ12_RS06090 Protein ID WP_003405863.1
Coordinates 1243399..1243596 (+) Length 66 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ12_RS06070 1239440..1240078 - 639 WP_003898730.1 lipid droplet-associated protein -
CPZ12_RS06075 1240168..1241175 + 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
CPZ12_RS06080 1241192..1242175 - 984 WP_003898731.1 hypothetical protein -
CPZ12_RS06085 1242238..1243311 + 1074 WP_003898732.1 redox-regulated ATPase YchF -
CPZ12_RS06090 1243399..1243596 + 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CPZ12_RS06095 1243593..1243967 + 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
CPZ12_RS06100 1244170..1244868 + 699 WP_003898733.1 hypothetical protein -
CPZ12_RS06105 1244986..1245171 + 186 WP_003901093.1 hypothetical protein -
CPZ12_RS06110 1245098..1245373 - 276 WP_003405867.1 hypothetical protein -
CPZ12_RS06115 1245616..1245939 + 324 WP_003405871.1 antibiotic biosynthesis monooxygenase -
CPZ12_RS06120 1245954..1246664 - 711 WP_003911399.1 hypothetical protein -
CPZ12_RS22005 1246686..1246895 + 210 WP_003911400.1 hypothetical protein -
CPZ12_RS06125 1246847..1247554 - 708 Protein_1163 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-111)

Antitoxin

(1-42)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T31590 WP_003405865.1 NZ_AP018035:1243593-1243967 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T31590 NZ_AP018035:1243593-1243967 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT31590 WP_003405863.1 NZ_AP018035:1243399-1243596 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT31590 NZ_AP018035:1243399-1243596 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TH08


Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References