Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2856526..2857235 Replicon chromosome
Accession NZ_AP018034
Organism Mycobacterium tuberculosis strain HN-205

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag CPZ09_RS13865 Protein ID WP_003413164.1
Coordinates 2856526..2856939 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag CPZ09_RS13870 Protein ID WP_003413167.1
Coordinates 2856978..2857235 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ09_RS13830 2851580..2852785 - 1206 WP_003413027.1 chorismate synthase -
CPZ09_RS13835 2852893..2853207 + 315 WP_009937839.1 hypothetical protein -
CPZ09_RS13840 2853503..2854714 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
CPZ09_RS13850 2854841..2855500 + 660 WP_003902296.1 hypothetical protein -
CPZ09_RS13855 2855497..2856159 + 663 WP_003905878.1 hypothetical protein -
CPZ09_RS13860 2856156..2856433 + 278 Protein_2618 type II toxin-antitoxin system VapB family antitoxin -
CPZ09_RS13865 2856526..2856939 + 414 WP_003413164.1 PIN domain nuclease Toxin
CPZ09_RS13870 2856978..2857235 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
CPZ09_RS13875 2857232..2857609 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
CPZ09_RS13880 2857625..2857999 - 375 WP_003413177.1 hypothetical protein -
CPZ09_RS13885 2858099..2858494 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
CPZ09_RS13890 2858491..2858736 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
CPZ09_RS13900 2859147..2859566 - 420 WP_003413190.1 A24 family peptidase -
CPZ09_RS13905 2859578..2860387 - 810 WP_003413193.1 shikimate dehydrogenase -
CPZ09_RS13910 2860384..2861634 - 1251 WP_024753809.1 endolytic transglycosylase MltG -
CPZ09_RS13915 2861627..2862139 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T31552 WP_003413164.1 NZ_AP018034:2856526-2856939 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T31552 NZ_AP018034:2856526-2856939 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT31552 WP_003413167.1 NZ_AP018034:2856978-2857235 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT31552 NZ_AP018034:2856978-2857235 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References