Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3759797..3760326 Replicon chromosome
Accession NZ_AP018033
Organism Mycobacterium tuberculosis strain HN-024

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag CPZ07_RS18195 Protein ID WP_003417760.1
Coordinates 3760069..3760326 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag CPZ07_RS18190 Protein ID WP_003417757.1
Coordinates 3759797..3760072 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ07_RS21925 3756595..3758032 - 1438 Protein_3433 FAD-binding oxidoreductase -
CPZ07_RS18175 3758135..3758524 + 390 WP_003417745.1 DUF732 domain-containing protein -
CPZ07_RS18180 3758538..3758831 - 294 WP_031663850.1 DUF3017 domain-containing protein -
CPZ07_RS18185 3758828..3759673 - 846 WP_003905054.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
CPZ07_RS18190 3759797..3760072 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
CPZ07_RS18195 3760069..3760326 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
CPZ07_RS18200 3760368..3761558 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
CPZ07_RS18205 3761675..3762043 + 369 WP_003417765.1 FHA domain-containing protein -
CPZ07_RS18210 3762040..3762591 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
CPZ07_RS18215 3762598..3763179 - 582 WP_031662192.1 ATP/GTP-binding protein -
CPZ07_RS18220 3763160..3763528 - 369 WP_003417772.1 DUF742 domain-containing protein -
CPZ07_RS18225 3763506..3763898 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T31506 WP_003417760.1 NZ_AP018033:3760069-3760326 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T31506 NZ_AP018033:3760069-3760326 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT31506 WP_003417757.1 NZ_AP018033:3759797-3760072 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT31506 NZ_AP018033:3759797-3760072 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References