Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3694134..3694808 Replicon chromosome
Accession NZ_AP018033
Organism Mycobacterium tuberculosis strain HN-024

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag CPZ07_RS17965 Protein ID WP_003417282.1
Coordinates 3694134..3694562 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag CPZ07_RS17970 Protein ID WP_003417286.1
Coordinates 3694566..3694808 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ07_RS17940 3689956..3690357 - 402 WP_003417264.1 cytidine deaminase -
CPZ07_RS17945 3690498..3690932 + 435 WP_072460198.1 succinate dehydrogenase, cytochrome b556 subunit -
CPZ07_RS17950 3690929..3691363 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
CPZ07_RS17955 3691492..3693264 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
CPZ07_RS17960 3693264..3694055 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
CPZ07_RS17965 3694134..3694562 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
CPZ07_RS17970 3694566..3694808 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
CPZ07_RS17975 3694930..3695544 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
CPZ07_RS17980 3695541..3696206 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
CPZ07_RS17985 3696207..3696740 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
CPZ07_RS17990 3696737..3697111 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
CPZ07_RS17995 3697208..3698272 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T31505 WP_003417282.1 NZ_AP018033:c3694562-3694134 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T31505 NZ_AP018033:c3694562-3694134 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT31505 WP_003417286.1 NZ_AP018033:c3694808-3694566 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT31505 NZ_AP018033:c3694808-3694566 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References