31495

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2868879..2869516 Replicon chromosome
Accession NZ_AP018033
Organism Mycobacterium tuberculosis strain HN-024

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag CPZ07_RS13880 Protein ID WP_003413180.1
Coordinates 2868879..2869274 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag CPZ07_RS13885 Protein ID WP_003413183.1
Coordinates 2869271..2869516 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ07_RS13840 2864964..2865623 + 660 WP_003900846.1 LppA family lipoprotein -
CPZ07_RS13845 2865620..2866279 + 660 WP_003900847.1 hypothetical protein -
CPZ07_RS13850 2866276..2866938 + 663 WP_055351404.1 hypothetical protein -
CPZ07_RS13855 2866935..2867213 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
CPZ07_RS13860 2867306..2867719 + 414 WP_003413164.1 PIN domain nuclease -
CPZ07_RS13865 2867758..2868015 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
CPZ07_RS13870 2868012..2868389 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
CPZ07_RS13875 2868405..2868779 - 375 WP_003413177.1 hypothetical protein -
CPZ07_RS13880 2868879..2869274 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
CPZ07_RS13885 2869271..2869516 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
CPZ07_RS13895 2869927..2870346 - 420 WP_003413190.1 A24 family peptidase -
CPZ07_RS13900 2870358..2871167 - 810 WP_003413193.1 shikimate dehydrogenase -
CPZ07_RS13905 2871164..2872420 - 1257 WP_014585306.1 endolytic transglycosylase MltG -
CPZ07_RS13910 2872413..2872925 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T31495 WP_003413180.1 NZ_AP018033:c2869274-2868879 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T31495 NZ_AP018033:c2869274-2868879 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT31495 WP_003413183.1 NZ_AP018033:c2869516-2869271 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT31495 NZ_AP018033:c2869516-2869271 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References