Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2867306..2868015 Replicon chromosome
Accession NZ_AP018033
Organism Mycobacterium tuberculosis strain HN-024

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag CPZ07_RS13860 Protein ID WP_003413164.1
Coordinates 2867306..2867719 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag CPZ07_RS13865 Protein ID WP_003413167.1
Coordinates 2867758..2868015 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ07_RS13825 2863016..2863330 + 315 WP_009937839.1 hypothetical protein -
CPZ07_RS13830 2863626..2864837 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
CPZ07_RS13840 2864964..2865623 + 660 WP_003900846.1 LppA family lipoprotein -
CPZ07_RS13845 2865620..2866279 + 660 WP_003900847.1 hypothetical protein -
CPZ07_RS13850 2866276..2866938 + 663 WP_055351404.1 hypothetical protein -
CPZ07_RS13855 2866935..2867213 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
CPZ07_RS13860 2867306..2867719 + 414 WP_003413164.1 PIN domain nuclease Toxin
CPZ07_RS13865 2867758..2868015 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
CPZ07_RS13870 2868012..2868389 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
CPZ07_RS13875 2868405..2868779 - 375 WP_003413177.1 hypothetical protein -
CPZ07_RS13880 2868879..2869274 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
CPZ07_RS13885 2869271..2869516 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
CPZ07_RS13895 2869927..2870346 - 420 WP_003413190.1 A24 family peptidase -
CPZ07_RS13900 2870358..2871167 - 810 WP_003413193.1 shikimate dehydrogenase -
CPZ07_RS13905 2871164..2872420 - 1257 WP_014585306.1 endolytic transglycosylase MltG -
CPZ07_RS13910 2872413..2872925 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T31493 WP_003413164.1 NZ_AP018033:2867306-2867719 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T31493 NZ_AP018033:2867306-2867719 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT31493 WP_003413167.1 NZ_AP018033:2867758-2868015 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT31493 NZ_AP018033:2867758-2868015 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References