Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2201030..2201574 | Replicon | chromosome |
| Accession | NZ_AP018033 | ||
| Organism | Mycobacterium tuberculosis strain HN-024 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | CPZ07_RS10545 | Protein ID | WP_003409896.1 |
| Coordinates | 2201030..2201326 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | CPZ07_RS10550 | Protein ID | WP_003409899.1 |
| Coordinates | 2201323..2201574 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPZ07_RS10490 | 2196063..2196413 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| CPZ07_RS10495 | 2196424..2197326 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| CPZ07_RS10500 | 2197347..2197538 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| CPZ07_RS10505 | 2197539..2197835 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| CPZ07_RS10510 | 2198075..2198290 | + | 216 | WP_003409878.1 | antitoxin | - |
| CPZ07_RS10515 | 2198287..2198598 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| CPZ07_RS21610 | 2198572..2199093 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| CPZ07_RS10525 | 2199068..2199445 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| CPZ07_RS10530 | 2199487..2199936 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| CPZ07_RS10535 | 2199933..2200478 | + | 546 | WP_031663732.1 | hypothetical protein | - |
| CPZ07_RS10540 | 2200367..2200981 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| CPZ07_RS10545 | 2201030..2201326 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CPZ07_RS10550 | 2201323..2201574 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| CPZ07_RS10555 | 2201561..2202055 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| CPZ07_RS10560 | 2202215..2202622 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| CPZ07_RS10565 | 2202626..2202898 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| CPZ07_RS10570 | 2202931..2204151 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| CPZ07_RS10585 | 2205050..2205847 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T31482 WP_003409896.1 NZ_AP018033:c2201326-2201030 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T31482 NZ_AP018033:c2201326-2201030 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT31482 WP_003409899.1 NZ_AP018033:c2201574-2201323 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT31482 NZ_AP018033:c2201574-2201323 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |