Detailed information of TA system TA031445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 120062..120856
• Replicon: chromosome
• Accession: NZ_AP017977
• Organism: Neochlamydia sp. S13

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: TY21_RS11240
• Protein ID: WP_197725065.1
• Coordinates: 120062..120391 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A3Q9XZB6
• Locus tag: TY21_RS00475
• Protein ID: WP_042242709.1
• Coordinates: 120392..120856 (-)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TY21_RS00450	116246..117646	+	1401	WP_042242718.1	alpha/beta hydrolase	-
TY21_RS00460	118307..119119	-	813	WP_158622986.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
TY21_RS00465	119158..119745	-	588	WP_042242712.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
TY21_RS11240	120062..120391	-	330	WP_197725065.1	PIN domain-containing protein	Toxin
TY21_RS00475	120392..120856	-	465	WP_042242709.1	helix-turn-helix domain-containing protein	Antitoxin
TY21_RS11245	121283..121570	+	288	WP_042242706.1	hypothetical protein	-
TY21_RS00485	121716..122129	+	414	WP_042242703.1	hypothetical protein	-
TY21_RS00490	122393..122671	-	279	WP_042242700.1	translation initiation factor	-
TY21_RS00495	122712..123494	-	783	WP_042242697.1	ABC transporter permease	-
TY21_RS00500	123484..124419	-	936	WP_052354602.1	ABC transporter ATP-binding protein	-
TY21_RS00505	124655..125791	+	1137	WP_158622987.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Helix-turn-helix domain, group 17 (84-131)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12992.02 Da
• Isoelectric Point: 5.5971

>T31445 WP_197725065.1 NZ_AP017977:c120391-120062 [Neochlamydia sp. S13]
MASFIVIYDSCVLYPAPLRDLLMRLALTELYQAKWTKDIHCEWMRSLLKNRSDLTEERLEMTRAKMDLHVKDCLVFDYEE
LIDNLKLPDPDDRHVLSSHQSKRTNYCDL

Nucleotide

• Length: 330 bp

>T31445 NZ_AP017977:c120391-120062 [Neochlamydia sp. S13]
ATGGCTAGCTTTATCGTGATTTATGACTCATGCGTCTTGTATCCAGCTCCTCTAAGAGATCTTCTGATGCGACTCGCATT
AACAGAGCTTTATCAAGCGAAATGGACAAAAGATATTCATTGCGAATGGATGCGCAGCCTTTTAAAAAATCGATCGGACT
TGACTGAAGAGCGTCTGGAAATGACACGAGCCAAAATGGACTTACATGTCAAAGATTGTTTAGTTTTTGACTATGAAGAG
CTGATTGACAATTTGAAGCTACCAGACCCAGATGATCGACATGTATTAAGCAGCCATCAAAGCAAACGCACAAACTATTG
TGACCTATAG

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 17538.40 Da
• Isoelectric Point: 6.4871

>AT31445 WP_042242709.1 NZ_AP017977:c120856-120392 [Neochlamydia sp. S13]
MQSFHLPEPIMPSESEVELARASSRILSSMDLQKGKTVKILLETDNYQQSSVTLPFSAFKLLMTVLTQMAEGNAITLIPV
HAELTTQEAADLLNVSRPYLIRLLEEKKIPFRKVGTRRRILFQDLMDYKAKIDAARRKILDELAEEAQNLDMGY

Nucleotide

• Length: 465 bp

>AT31445 NZ_AP017977:c120856-120392 [Neochlamydia sp. S13]
ATGCAATCTTTTCACTTACCTGAGCCTATTATGCCTAGCGAAAGCGAGGTAGAATTAGCTCGAGCTTCTAGCCGTATCCT
TTCTTCCATGGACTTGCAGAAAGGAAAAACCGTTAAAATCCTACTTGAAACTGATAATTATCAACAGAGTTCGGTTACCT
TGCCTTTTTCAGCCTTTAAGCTGTTGATGACAGTGCTCACTCAAATGGCAGAAGGAAATGCAATCACGTTAATTCCTGTG
CATGCGGAACTTACAACCCAAGAAGCTGCAGATTTACTTAACGTTTCACGCCCTTATCTGATTCGACTTCTAGAAGAAAA
AAAAATTCCCTTTCGTAAGGTAGGGACAAGGCGCCGAATTCTGTTCCAAGATTTAATGGATTATAAGGCTAAAATTGACG
CAGCACGTCGTAAAATTCTAGATGAGTTGGCTGAAGAAGCACAAAACCTGGATATGGGATATTAA

Structures

Antitoxin

• AlphaFold DB: A0A3Q9XZB6