Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1687566..1688234 Replicon chromosome
Accession NZ_AP017971
Organism Streptococcus pneumoniae strain KK0981

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag KK0981_RS08995 Protein ID WP_001132282.1
Coordinates 1688055..1688234 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag KK0981_RS08990 Protein ID WP_000961810.1
Coordinates 1687566..1688018 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK0981_RS08970 1684415..1685449 - 1035 WP_000747916.1 ATP-binding protein -
KK0981_RS08975 1685559..1685717 - 159 WP_000418159.1 7,8-dihydro-8-oxoguanine-triphosphatase -
KK0981_RS08980 1685698..1686786 - 1089 WP_000719711.1 M50 family metallopeptidase -
KK0981_RS08985 1686805..1687275 - 471 WP_000257114.1 DUF3013 family protein -
KK0981_RS08990 1687566..1688018 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KK0981_RS08995 1688055..1688234 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
KK0981_RS09000 1688371..1688550 - 180 WP_001048906.1 hypothetical protein -
KK0981_RS09005 1688715..1688954 - 240 WP_000818079.1 hypothetical protein -
KK0981_RS09015 1689224..1690495 + 1272 WP_001113205.1 replication-associated recombination protein A -
KK0981_RS09025 1691040..1692359 - 1320 WP_096376138.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T31443 WP_001132282.1 NZ_AP017971:c1688234-1688055 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T31443 NZ_AP017971:c1688234-1688055 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT31443 WP_000961810.1 NZ_AP017971:c1688018-1687566 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT31443 NZ_AP017971:c1688018-1687566 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References