Detailed information of TA system TA031441

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1175857..1176355
• Replicon: chromosome
• Accession: NZ_AP017971
• Organism: Streptococcus pneumoniae strain KK0981

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KK0981_RS06255
• Protein ID: WP_001812387.1
• Coordinates: 1175857..1176111 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: KK0981_RS06260
• Protein ID: WP_000208080.1
• Coordinates: 1176113..1176355 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KK0981_RS06240	1171126..1173594	-	2469	WP_016398190.1	DNA gyrase subunit A	-
KK0981_RS06245	1173788..1174774	+	987	WP_096376124.1	L-lactate dehydrogenase	-
KK0981_RS06250	1175037..1175810	-	774	WP_000731126.1	ion transporter	-
KK0981_RS06255	1175857..1176111	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KK0981_RS06260	1176113..1176355	-	243	WP_000208080.1	hypothetical protein	Antitoxin
KK0981_RS06265	1176446..1177255	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
KK0981_RS06270	1177257..1178606	-	1350	WP_050201324.1	cell wall metabolism sensor histidine kinase VicK	-
KK0981_RS06275	1178599..1179303	-	705	WP_000722076.1	response regulator transcription factor	-
KK0981_RS06280	1179358..1180533	-	1176	WP_000886145.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T31441 WP_001812387.1 NZ_AP017971:c1176111-1175857 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T31441 NZ_AP017971:c1176111-1175857 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT31441 WP_000208080.1 NZ_AP017971:c1176355-1176113 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT31441 NZ_AP017971:c1176355-1176113 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTAGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7