31440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 1093029..1094275 Replicon chromosome
Accession NZ_AP017971
Organism Streptococcus pneumoniae strain KK0981

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag KK0981_RS05835 Protein ID WP_000405346.1
Coordinates 1093505..1094275 (+) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag KK0981_RS05830 Protein ID WP_000579602.1
Coordinates 1093029..1093505 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK0981_RS05795 1088190..1089074 - 885 WP_000583376.1 Rgg/GadR/MutR family transcriptional regulator -
KK0981_RS05805 1090249..1090890 + 642 WP_000933083.1 hypothetical protein -
KK0981_RS05810 1090900..1091985 + 1086 Protein_1085 toprim domain-containing protein -
KK0981_RS05815 1092036..1092269 + 234 WP_000152423.1 hypothetical protein -
KK0981_RS05820 1092266..1092649 + 384 WP_000159208.1 hypothetical protein -
KK0981_RS05825 1092687..1092959 + 273 WP_000495448.1 hypothetical protein -
KK0981_RS05830 1093029..1093505 + 477 WP_000579602.1 helix-turn-helix domain-containing protein Antitoxin
KK0981_RS05835 1093505..1094275 + 771 WP_000405346.1 zeta toxin family protein Toxin
KK0981_RS05840 1094629..1095525 - 897 WP_000384882.1 tyrosine-type recombinase/integrase -
KK0981_RS05845 1095619..1096182 + 564 WP_001060373.1 hypothetical protein -
KK0981_RS05850 1096235..1096612 + 378 WP_000821055.1 hypothetical protein -
KK0981_RS05855 1096623..1097603 + 981 WP_000916686.1 caspase family protein -
KK0981_RS05860 1097625..1098866 - 1242 WP_000342171.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1083191..1135502 52311


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(24-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29461.45 Da        Isoelectric Point: 7.9259

>T31440 WP_000405346.1 NZ_AP017971:1093505-1094275 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNIRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHTHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYILNPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAAEVLQEYLFGKWSKVEEEML
KSGEERLKDLTNRNGC

Download         Length: 771 bp

>T31440 NZ_AP017971:1093505-1094275 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATATTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATACACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAGCTGTCCTATCTGAGCACTCTTATCCGATACGAAGAA
CTGTACATTCTCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTGGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGAAGTGCTACAAGAATACCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATCGAAATGGTTGTTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18289.70 Da        Isoelectric Point: 4.4188

>AT31440 WP_000579602.1 NZ_AP017971:1093029-1093505 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT31440 NZ_AP017971:1093029-1093505 [Streptococcus pneumoniae]
ATGATTGGAAAAAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References