Detailed information of TA system TA031439

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 2193204..2193652
• Replicon: chromosome
• Accession: NZ_AP017959
• Organism: Synechococcus sp. NIES-970

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: NIES970_RS10375
• Protein ID: WP_096418461.1
• Coordinates: 2193204..2193437 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: NIES970_RS10380
• Protein ID: WP_096418463.1
• Coordinates: 2193437..2193652 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIES970_RS10355	2188355..2189263	+	909	WP_096418455.1	pentapeptide repeat-containing protein	-
NIES970_RS10360	2189299..2189679	+	381	WP_024546699.1	hypothetical protein	-
NIES970_RS10365	2189732..2192059	-	2328	WP_096418457.1	1,4-alpha-glucan branching enzyme	-
NIES970_RS10370	2192356..2193135	-	780	WP_096418459.1	hydroxyacylglutathione hydrolase	-
NIES970_RS10375	2193204..2193437	-	234	WP_096418461.1	type II toxin-antitoxin system HicA family toxin	Toxin
NIES970_RS10380	2193437..2193652	-	216	WP_096418463.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
NIES970_RS10385	2193792..2194706	-	915	WP_096418465.1	branched-chain amino acid transaminase	-
NIES970_RS10390	2194792..2196567	-	1776	WP_096418467.1	M61 family metallopeptidase	-
NIES970_RS10395	2196583..2197263	-	681	WP_024546694.1	Crp/Fnr family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-64)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (8-60)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8636.28 Da
• Isoelectric Point: 11.2826

>T31439 WP_096418461.1 NZ_AP017959:c2193437-2193204 [Synechococcus sp. NIES-970]
MVSLPTVNAQQIIKILQKLGFEITRQKGSHIRLKHGDGRVVTVPVHSGKNLGKGLLLKILRDVQISKEEFVQLLQKN

Nucleotide

• Length: 234 bp

>T31439 NZ_AP017959:c2193437-2193204 [Synechococcus sp. NIES-970]
ATGGTATCACTACCCACAGTAAATGCTCAGCAAATTATCAAAATTCTCCAGAAACTAGGCTTTGAGATTACTCGCCAGAA
AGGGAGTCACATTCGCCTCAAACATGGAGATGGCAGAGTTGTAACGGTTCCGGTTCACAGCGGTAAAAATCTTGGTAAGG
GTCTACTGCTCAAAATTCTTAGAGATGTTCAAATTTCCAAAGAAGAATTCGTTCAATTATTACAGAAGAACTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 3.8403

>AT31439 WP_096418463.1 NZ_AP017959:c2193652-2193437 [Synechococcus sp. NIES-970]
MSKNNTEFYVLIEKDEDGFYVGEVPQLQGCYSQGETIDELMKNMREVIELCLEELEEESKNEFIGIQKITV

Nucleotide

• Length: 216 bp

>AT31439 NZ_AP017959:c2193652-2193437 [Synechococcus sp. NIES-970]
ATGTCCAAAAATAATACTGAATTTTATGTTTTAATCGAAAAAGATGAAGATGGATTCTATGTTGGCGAAGTCCCTCAACT
GCAAGGGTGTTACAGTCAGGGAGAAACTATTGACGAACTCATGAAAAATATGAGAGAAGTCATTGAGCTTTGTCTTGAAG
AGTTAGAAGAAGAATCTAAAAATGAGTTTATCGGTATCCAAAAAATAACTGTTTAA